Multicentric Castleman's disease: Report of three cases

Castleman's disease is an uncommon benign B-cell lymphoproliferative disorder. According to lymph nodes distribution, there are two distinct subtypes of disease: unicentric and multicentric. Unicentric Castleman's disease is more common, localized to one site, and locally treated. On the c...

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Bibliographic Details
Published in:Radiology case reports 2019-03, Vol.14 (3), p.328-332
Main Authors: Guazzaroni, M, Bocchinfuso, F, Vasili, E, Lacchè, A, Ranalli, T, Garipoli, A, Di Tosto, F, Floris, R
Format: Article
Language:English
Subjects:
Diagnostic Imaging
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Summary:Castleman's disease is an uncommon benign B-cell lymphoproliferative disorder. According to lymph nodes distribution, there are two distinct subtypes of disease: unicentric and multicentric. Unicentric Castleman's disease is more common, localized to one site, and locally treated. On the contrary, multicentric form is a rare systemic disease characterized by diffuse lymphadenopathy and inflammatory symptoms. We report three cases of persons that were initially suspected to have a lymphoma but were later histologically confirmed to have Multicentric Castleman's Disease. In addition, our work aims to investigate the role of fluorodeoxyglucose (FDG) PET/CT in evaluation of this rare condition.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2018.10.005