Gene polymorphism of blood coagulation factors and endothelial dysfunction in early and late preeclampsia

The aim of our study was to find out the influence of gene polymorphisms of coagulation factors, endothelial dysfunction and regulators of blood pressure in early (EPE) and late preeclampsia (LPE). The study of genetic polymorphisms of blood coagulation factors and fibrinolysis (1691 G/A factor V Le...

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Bibliographic Details
Published in:Medychni perspektyvy 2020-07, Vol.25 (2), p.66-71
Main Authors: Loskutova, T. O., Demchenko, T. V., Kryachkova, N. V.
Format: Article
Language:English
Subjects:
gene polymorphism
obstetric and perinatal complications
pre-eclampsia
pregnancy
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Summary:The aim of our study was to find out the influence of gene polymorphisms of coagulation factors, endothelial dysfunction and regulators of blood pressure in early (EPE) and late preeclampsia (LPE). The study of genetic polymorphisms of blood coagulation factors and fibrinolysis (1691 G/A factor V Leiden (FVL), 20210 G/A prothrombin, -675 5G/4G PAI-1, 455 G/A fibrinogen β), endothelial dysfunction (192 Q → R paraoxonase 1, 677 C/T MTHFR, arterial pressure regulator (235 M/T angio­tensinogen II (AGT II)) using an PCR was performed. A prospective cohort study of 39 women with EPE, 93 with LPE and 44 pregnant women with a physiological pregnancy (C group) was conducted. The average gestational age at the time of delivery in EPE group was lower than in LPE and control group (p
ISSN:2307-0404
DOI:10.26641/2307-0404.2020.2.206363