Role of lipid transporters in fungal physiology and pathogenicity

The fungal cell wall and membrane are the most common targets of antifungal agents, but the potential of membrane lipid organization in regulating drug-target interactions has yet to be investigated. Energy-dependent lipid transporters have been recently associated with virulence and drug resistance...

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Bibliographic Details
Published in:Computational and structural biotechnology journal 2019-01, Vol.17, p.1278-1289
Main Authors: Rizzo, Juliana, Stanchev, Lyubomir Dimitrov, da Silva, Vanessa K.A., Nimrichter, Leonardo, Pomorski, Thomas Günther, Rodrigues, Marcio L.
Format: Article
Language:English
Subjects:
ABC transporters
Antifungals
Flippases
Fungal infections
Phosphatidylethanolamine
Phosphatidylserine
Review
Sterols
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Summary:The fungal cell wall and membrane are the most common targets of antifungal agents, but the potential of membrane lipid organization in regulating drug-target interactions has yet to be investigated. Energy-dependent lipid transporters have been recently associated with virulence and drug resistance in many pathogenic fungi. To illustrate this view, we discuss (i) the structural and biological aspects of ATP-driven lipid transporters, comprising P-type ATPases and ATP-binding cassette transporters, (ii) the role of these transporters in fungal physiology and virulence, and (iii) the potential of lipid transporters as targets for the development of novel antifungals. These recent observations indicate that the lipid-trafficking machinery in fungi is a promising target for studies on physiology, pathogenesis and drug development. [Display omitted]
ISSN:2001-0370
2001-0370
DOI:10.1016/j.csbj.2019.09.001