Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand

Multimetallic complexes have been shown in several examples to possess greater anticancer activity than their monometallic counterparts. The increased activity has been attributed to altered modes of action. We herein report the synthesis of a series of heterodimetallic compounds based on a ditopic...

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Bibliographic Details
Published in:Frontiers in chemistry 2021-12, Vol.9, p.786367-786367
Main Authors: Green, Lewis P M, Steel, Tasha R, Riisom, Mie, Hanif, Muhammad, Söhnel, Tilo, Jamieson, Stephen M F, Wright, L James, Crowley, James D, Hartinger, Christian G
Format: Article
Language:English
Subjects:
anticancer activity
bioorganometallics
Chemistry
heterodimetallic complexes
ligand exchange reactions
structural characterization
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Summary:Multimetallic complexes have been shown in several examples to possess greater anticancer activity than their monometallic counterparts. The increased activity has been attributed to altered modes of action. We herein report the synthesis of a series of heterodimetallic compounds based on a ditopic ligand featuring 2-pyridylimine chelating motifs and organometallic half-sandwich moieties. The complexes were characterized by a combination of H NMR spectroscopy, electrospray ionization mass spectrometry, elemental analysis and single crystal X-ray diffraction. Investigations into the stability of representative complexes in DMSO- and 10% DMSO- /D O revealed the occurrence of solvent-chlorido ligand exchange. Proliferation assays in four human cancer cell lines showed that the Os-Rh complex possessed minimal activity, while all other complexes were inactive.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2021.786367