Interstitial and Langerhans' dendritic cells in chronic periodontitis and gingivitis

The aim of the present study was to compare quantitatively the distribution of dendritic cell subpopulations in chronic periodontitis and gingivitis. Fourteen biopsies from patients with chronic periodontitis and fifteen from patients with gingivitis were studied. An immunoperoxidase technique was u...

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Published in:Brazilian oral research 2008-09, Vol.22 (3), p.258-263
Main Authors: Cury, Patricia Ramos, Furuse, Cristiane, Rodrigues, Ana Elisa Amaro, Barbuto, José Alexandre, Araújo, Vera Cavalcanti de, Araújo, Ney Soares de
Format: Article
Language:English
Subjects:
Adult
Antigens, CD1 - analysis
Antigens, CD1 - immunology
Biomarkers - analysis
Biopsy
CD1a
Chronic Periodontitis - pathology
Dendritic cells
Dentistry
Factor XIIIa
Factor XIIIa - analysis
Factor XIIIa - immunology
Female
Gingiva - pathology
Gingivitis
Gingivitis - immunology
Gingivitis - pathology
Humans
Langerhans Cells - immunology
Langerhans Cells - pathology
Male
Monocytes
Periodontitis
Statistics, Nonparametric
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Summary:The aim of the present study was to compare quantitatively the distribution of dendritic cell subpopulations in chronic periodontitis and gingivitis. Fourteen biopsies from patients with chronic periodontitis and fifteen from patients with gingivitis were studied. An immunoperoxidase technique was used to quantify the number of Langerhans' cells (CD1a) and interstitial dendritic cells (factor XIIIa) in the oral and sulcular and junctional/pocket epithelia and in the lamina propria. A greater number of factor XIIIa+ dendritic cells in the lamina propria and CD1a+ dendritic cells in the oral epithelium were observed in gingivitis compared to the periodontitis group (p = 0.05). In the sulcular and junctional/pocket epithelia and in the lamina propria, the number of CD1a+ dendritic cells was similar in the gingivitis and periodontitis groups. In conclusion, the number of Langerhans' cells in the oral epithelium and interstitial dendritic cells in the lamina propria is increased in gingivitis compared to periodontitis, which may contribute to the different pattern of host response in these diseases.
ISSN:1806-8324
1807-3107
1806-8324
DOI:10.1590/S1806-83242008000300012