Equine Gram-Negative Oral Microbiota: An Antimicrobial Resistances Watcher?

Horses are considered as reservoirs of multidrug resistant bacteria that can be spread through the environment and possibly to humans. The aim of this study was to characterize the oral Gram-negative microbiota of healthy horses and evaluate their antimicrobial susceptibility profile in a One Health...

Full description

Saved in:
Bibliographic Details
Published in:Antibiotics (Basel) 2023-04, Vol.12 (4), p.792
Main Authors: Pimenta, José, Pinto, Ana Rita, Saavedra, Maria José, Cotovio, Mário
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
antimicrobials
Bacteria
Carbapenems
Drug resistance
Drug resistance in microorganisms
E coli
equine
Geographical locations
Health care
Horses
Infections
Infectious diseases
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Multidrug resistance
One Health
oral microbiota
Pathogens
Public health
Quinolones
Sulfonamides
Tetracycline
Tetracyclines
Ticarcillin
Veterinary medicine
Zoonoses
β-Lactam antibiotics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Horses are considered as reservoirs of multidrug resistant bacteria that can be spread through the environment and possibly to humans. The aim of this study was to characterize the oral Gram-negative microbiota of healthy horses and evaluate their antimicrobial susceptibility profile in a One Health approach. For this purpose, samples were collected from the gingival margin of healthy horses, free of antimicrobial therapy, cultured in selective mediums, identified, and tested for antimicrobial susceptibility. Fifty-five Gram-negative isolates were identified, with 89.5% being zoonotic and 62% affecting humans, which were also found commonly in the environment. Forty-eight isolates (96%) were MDR. The phenotypic resistance presented as higher to macrolides (81.8%), β-lactams (55.4%), and quinolones (50%), and lower to sulfonamides (27.3%), tetracyclines, and amphenicols (both with 30.9%). In total, 51.5% of the isolates presented resistance to carbapenems. In addition to being the first report on the commensal oral microbiota of horses and respective susceptibility profile, this study highlights the horse as a valuable sentinel that can control the evolution and transmission of multidrug-resistant bacteria between the "One Health triad" since it is in contact with humans, other animals, and the environment, in different geographic locations.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12040792