The Role of Rho GTPases in VEGF Signaling in Cancer Cells

Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream molecular pathways have been thoroughly studi...

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Bibliographic Details
Published in:Analytical cellular pathology (Amsterdam) 2020, Vol.2020 (2020), p.1-11
Main Authors: Fakhoury, Isabelle, Jaafar, Leila, Khalil, Elie Abi, Farran, Mohammad, El Baba, Nada, El-Sibai, Mirvat
Format: Article
Language:English
Subjects:
Animals
Biochemistry, biophysics & molecular biology
Biochimie, biophysique & biologie moléculaire
Cancer
Cancer cells
Cancer Research
Carcinogenesis
Carcinogenesis - metabolism
Carcinogenesis - pathology
Cell Biology
Cell interaction
Cellular signal transduction
General Medicine
Guanosine triphosphatase
Health aspects
Humans
Life sciences
Molecular Medicine
Neoplasms
Neoplasms - metabolism
Neoplasms - pathology
Neovascularization, Pathologic
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Oncology, Experimental
Pathology and Forensic Medicine
Physiological aspects
Review
rho GTP-Binding Proteins
rho GTP-Binding Proteins - metabolism
Sciences du vivant
Signal Transduction
Signal Transduction - physiology
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor A - metabolism
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Summary:Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream molecular pathways have been thoroughly studied. Activation of VEGF signal transduction can be initiated by the molecules’ binding to two classes of transmembrane receptors: (1) the VEGF tyrosine kinase receptors (VEGF receptors 1 through 3) and (2) the neuropilins (NRP1 and 2). The involvement of Rho GTPases in modulating VEGFA signaling in both cancer cells and endothelial cells has also been well established. Additionally, different isoforms of Rho GTPases, namely, RhoA, RhoC, and RhoG, have been shown to regulate VEGF expression as well as blood vessel formation. This review article will explore how Rho GTPases modulate VEGF signaling and the consequences of such interaction on cancer progression.
ISSN:2210-7177
2210-7185
2210-7185
DOI:10.1155/2020/2097214