Daptomycin and vancomycin non-susceptible methicillin-resistant Staphylococcus aureus clonal lineages from bloodstream infection in a Brazilian teaching hospital

This study aimed to characterize Staphylococcus aureus isolates from bloodstream infections in patients attending a teaching hospital, between 2011 and 2015. The minimum inhibitory concentration for daptomycin, linezolid, oxacillin, teicoplanin, vancomycin, and trimethoprim/sulfamethoxazole was acce...

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Published in:The Brazilian journal of infectious diseases 2019-03, Vol.23 (2), p.139-142
Main Authors: Damasco, Andreia Paredes, Costa, Thaina Miranda da, Morgado, Priscylla Guimarães Migueres, Guimarães, Lorrayne Cardoso, Cavalcante, Fernanda Sampaio, Nouér, Simone Aranha, Santos, Kátia Regina Netto dos
Format: Article
Language:English
Subjects:
Anopheles
Antibacterial agents
Bacteria
Bloodstream infection
Brief Communication
Daptomycin
Health aspects
Health screening
Infection
INFECTIOUS DISEASES
Linezolid
Medical tests
Methicillin
Microbial drug resistance
Mupirocin
Oxacillin
S. aureus
Staphylococcal infections
Staphylococcus aureus
Staphylococcus aureus infections
Teachers
Vancomycin
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Summary:This study aimed to characterize Staphylococcus aureus isolates from bloodstream infections in patients attending a teaching hospital, between 2011 and 2015. The minimum inhibitory concentration for daptomycin, linezolid, oxacillin, teicoplanin, vancomycin, and trimethoprim/sulfamethoxazole was accessed by broth microdilution. SCCmec type and clonal profile were determined by molecular tests. Vancomycin heteroresistance was evaluated using screening tests and by population analysis profile/area under the curve. Among 200 S. aureus isolates, 55 (27.5%) were MRSA, carrying SCCmec II (45.5%) or IV (54.5%). The most frequent MRSA lineages were USA100 (ST5-II) (45.5%) and USA800 (ST5-IV) (30.9%). Six isolates were confirmed as vancomycin heteroresistant, showing area under the curve ratio 1.1, 1.2 or 1.3 (four USA100, one USA800 and one USA1100 isolates). Daptomycin and vancomycin non-susceptible MRSA clonal lineages were found in bloodstream infections over five years, highlighting the importance of continuous surveillance of multiresistant bacteria in hospitals.
ISSN:1413-8670
1678-4391
1678-4391
DOI:10.1016/j.bjid.2019.03.003