Utility of the AVISE Connective Tissue Disease test in predicting lupus diagnosis and progression

BackgroundThe AVISE Connective Tissue Disease (CTD) test uses autoantibody, erythrocyte-bound C4d (EC4d) and B-cell-bound C4d (BC4d) levels to aid in diagnoses of SLE, other CTDs and fibromyalgia. We evaluated the utility of the AVISE CTD test in predicting SLE disease development and damage progres...

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Bibliographic Details
Published in:Lupus science & medicine 2020-03, Vol.7 (1), p.e000345-e000345
Main Authors: Liang, Emily, Taylor, Mihaela, McMahon, Maureen
Format: Article
Language:English
Subjects:
Adult
Aged
Autoantibodies - blood
Biomarkers
Classification
Connective Tissue Diseases - blood
damage
disease activity
Disease Progression
Epidemiology and Outcomes
Female
Fibromyalgia
Humans
inflammation
Laboratories
Longitudinal Studies
Lupus
Lupus Erythematosus, Systemic - diagnosis
Male
Middle Aged
Predictive Value of Tests
Retrospective Studies
Rheumatism
Rheumatoid arthritis
Rheumatology
Severity of Illness Index
SLE
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Summary:BackgroundThe AVISE Connective Tissue Disease (CTD) test uses autoantibody, erythrocyte-bound C4d (EC4d) and B-cell-bound C4d (BC4d) levels to aid in diagnoses of SLE, other CTDs and fibromyalgia. We evaluated the utility of the AVISE CTD test in predicting SLE disease development and damage progression.MethodsPatients who had undergone AVISE CTD testing were assessed for SLE diagnosis by the Systemic Lupus International Collaborating Clinics (SLICC) and American College of Rheumatology criteria and for SLE damage by the Systemic Lupus International Collaborating Clinics Damage Index (SDI) at the time of AVISE testing (t=0) and 2 years later (t=2).ResultsAmong 117 patients without a previous diagnosis of SLE, 65% of patients who tested positive developed SLE at t=2, compared with 10.3% of patients who tested non-positive (p
ISSN:2053-8790
2053-8790
DOI:10.1136/lupus-2019-000345