The predictive value of dynamic monitoring of peripheral blood lymphocyte to monocyte ratio in patients with extranodal NK/T cell lymphoma

• Published in: Cancer cell international 2019-10, Vol.19 (1), p.272-272, Article 272
• Main Authors: Zhang, Shengnan, Li, Mengjuan, Yuan, Fangfang, Chen, Lin, Mi, Ruihua, Wei, Xudong, Song, Yongping, Yin, Qingsong
• Format: Article
• Language: English
• Subjects: Dynamic monitoring; Extranodal NK/T cell lymphoma; Prognosis; Ratio of lymphocyte to monocyte; Review
• ISSN: 1475-2867; 1475-2867
• DOI: 10.1186/s12935-019-0993-9

To investigate the value of dynamic monitoring peripheral blood lymphocyte-to-monocyte (LMR) ratio in evaluating the treatment response and prognosis of patients with extranodal NK/T cell lymphoma (ENKTL). A total of 148 patients with ENKTL were retrospectively analyzed in the Affiliated Tumor Hospital of Zhengzhou University between March 2012 and March 2018. The optimal cut-off value of LMR was determined using the receiver operating characteristic curve (ROC) method, then patients were divided into low LMR group and high LMR group. The LMR level was dynamically measured at various time points, and the relationships between LMR and therapeutic response, and survival were analyzed. The complete remission rate (CR) was 85.7% in patients with high LMR at diagnosis, which was remarkably higher than that of patients with low LMR at diagnosis (64.9%) ( = 0.009). The 5-year overall survival (OS) and progression-free survival (PFS) were 49.28% and 44.89% in the low LMR group, respectively; 5-year OS and PFS in the high LMR group were 84.50% and 67.12%, respectively, significantly longer ( values were