A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in t...

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Bibliographic Details
Published in:Marine drugs 2015-07, Vol.13 (8), p.4594-4616
Main Authors: Wang, Yan-Ting, Xue, Ya-Rong, Liu, Chang-Hong
Format: Article
Language:English
Subjects:
Anti-Infective Agents - metabolism
Anti-Infective Agents - pharmacology
anticancer
antifungal
Antifungal Agents - metabolism
Antifungal Agents - pharmacology
antimicrobial
Antiprotozoal Agents - metabolism
Antiprotozoal Agents - pharmacology
antiviral
Antiviral Agents - metabolism
Antiviral Agents - pharmacology
bioactive compounds
Biological Factors - metabolism
Biological Factors - pharmacology
deep-sea fungi
Fungi - metabolism
Geologic Sediments - microbiology
Humans
Review
Seawater - microbiology
Secondary Metabolism - physiology
Structure-Activity Relationship
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Summary:Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.
ISSN:1660-3397
1660-3397
DOI:10.3390/md13084594