Clinical study on the status of transient thyrotoxicosis after surgery for secondary hyperparathyroidism patients with end-stage renal disease and normal thyroid function

Secondary hyperparathyroidism (SHPT) is a common complication of end-stage renal disease (ESRD), and part of SHPT patients need receive parathyroidectomy (PTX). However, as an important postoperative complication of SHPT, thyrotoxicosis has received little attention. Therefore, in this article, we a...

Full description

Saved in:
Bibliographic Details
Published in:European journal of medical research 2020-03, Vol.25 (1), p.7-7, Article 7
Main Authors: Zou, Bao-Shan, Liu, Jia-Shuo, Li, Hong, Xu, Zhou, Li, Hao, Li, Hong-Yuan, Wu, Kai-Nan, Kong, Ling-Quan
Format: Article
Language:English
Subjects:
Antibodies
Breast surgery
Chronic kidney disease
Chronic kidney failure
Clinical trials
Developing countries
Diseases
End-stage renal disease
Heat resistance
Hemodialysis
Hormones
Hyperparathyroidism
Immunoglobulins
Kidney diseases
LDCs
Metabolism
Parathyroid hormones
Parathyroidectomy
Secondary hyperparathyroidism
Studies
Surgery
Thyroid diseases
Thyroid gland
Thyroid hormones
Thyrotoxicosis
Thyrotropin
Thyroxine
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Secondary hyperparathyroidism (SHPT) is a common complication of end-stage renal disease (ESRD), and part of SHPT patients need receive parathyroidectomy (PTX). However, as an important postoperative complication of SHPT, thyrotoxicosis has received little attention. Therefore, in this article, we aimed to study the status of transient thyrotoxicosis after PTX for SHPT patients with ESRD and normal thyroid function. A total of 24 SHPT patients with preoperative normal thyroid function, normal thyroglobulin (Tg) and normal thyroid antibodies receiving PTX were enrolled from the Department of Endocrine and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, from January 2017 to January 2019. Tg, high sensitivity thyrotropin stimulating hormone (sTSH), triiodothyronine (T3), free triiodothyronine (fT3), thyroxine (T4) and free thyroxine (fT4) were evaluated the day before PTX and on day 1, 3 and 5 after PTX. Besides, all enrolled patients were evaluated whether there are symptoms associated with thyrotoxicosis. Among the 24 SHPT patients, 1 case (4.2%), 8 cases (33.3%) and 13 cases (54.2%) had suffered thyrotoxicosis at the first, third and fifth day after surgery, respectively. Serum FT4 level increased significantly from pre-operation (0.68 ± 0.15 ng/dl, normal range 0.59-1.25 ng/dl) to the third day after operation (1.91 ± 0.97 ng/dl, p
ISSN:2047-783X
0949-2321
2047-783X
DOI:10.1186/s40001-020-00405-6