Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the dynamic colon model

The dynamic colon model is a biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards (antegrade) and backwards (retrograde). This work studies the dissolution profile of theophylline from Uniphyllin...

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Bibliographic Details
Published in:British Journal of Pharmacy 2022-11, Vol.7 (2), p.S1-S2
Main Authors: O'Farrell, Connor, Stamatopoulos, Konstantinos, Simmons, Mark J. H., Batchelor, Hannah
Format: Article
Language:English
Subjects:
dissolution testing
Drugs
dynamic colon model
Gastrointestinal system
in vitro models
Inhomogeneous materials
modified release
Solubility
Testing
Therapeutic use
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Summary:The dynamic colon model is a biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards (antegrade) and backwards (retrograde). This work studies the dissolution profile of theophylline from Uniphyllin Continus 200 mg prolonged release tablets and the distribution of dissolved theophylline in viscosity-enhanced media under the influence of a cyclic retrograde peristaltic contraction. At 16- and 24-hours, 80.73 +- 3.28 and 95.4 +- 4.73 % theophylline dissolved from the tablet and the fluid inside the mimic intestinal system approached homogeneity.
ISSN:2058-8356
2058-8356
DOI:10.5920/bjpharm.1192