Similarities and differences in structure, expression, and functions of VLDLR and ApoER2

Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain. VLDLR and ApoER2 are members...

Full description

Saved in:
Bibliographic Details
Published in:Molecular neurodegeneration 2011-05, Vol.6 (1), p.30-30, Article 30
Main Authors: Reddy, Sunil S, Connor, Teal E, Weeber, Edwin J, Rebeck, William
Format: Article
Language:English
Subjects:
Gene expression
Neurons
Physiological aspects
Protein binding
Proteins
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain. VLDLR and ApoER2 are members of the low density lipoprotein family, which also mediates the effects of numerous other extracellular ligands, including apolipoprotein E. Although VLDLR and ApoER2 are highly homologous, they differ in a number of ways, including structural differences, expression patterns, alternative splicing, and binding of extracellular and intracellular proteins. This review aims to summarize important aspects of VLDLR and ApoER2 that may account for interesting recent findings that highlight the unique functions of each receptor.
ISSN:1750-1326
1750-1326
DOI:10.1186/1750-1326-6-30