Histone Deacetylase Inhibitors: A Novel Strategy for Neuroprotection and Cardioprotection Following Ischemia/Reperfusion Injury

Ischemia/reperfusion injury is a complex molecular cascade that causes deleterious cellular damage and organ dysfunction. Stroke, sudden cardiac arrest, and acute myocardial infarction are the most common causes of ischemia/reperfusion injury without effective pharmacologic therapies. Existing precl...

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Bibliographic Details
Published in:Journal of the American Heart Association 2020-06, Vol.9 (11), p.e016349
Main Authors: Pickell, Zachary, Williams, Aaron M, Alam, Hasan B, Hsu, Cindy H
Format: Article
Language:English
Subjects:
Animals
Basic Science for Clinicians
Brain - blood supply
Brain - drug effects
Brain - enzymology
Brain - pathology
cardiac arrest
Cardiovascular Agents - therapeutic use
Cerebrovascular Circulation
Coronary Circulation
Epigenesis, Genetic - drug effects
epigenetics
histone deacetylase inhibitors
Histone Deacetylase Inhibitors - therapeutic use
Humans
myocardial infarction
Myocardial Reperfusion Injury - enzymology
Myocardial Reperfusion Injury - pathology
Myocardial Reperfusion Injury - physiopathology
Myocardial Reperfusion Injury - prevention & control
Myocardium - enzymology
Myocardium - pathology
Neuroprotective Agents - therapeutic use
Reperfusion Injury - enzymology
Reperfusion Injury - pathology
Reperfusion Injury - physiopathology
Reperfusion Injury - prevention & control
stroke
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Summary:Ischemia/reperfusion injury is a complex molecular cascade that causes deleterious cellular damage and organ dysfunction. Stroke, sudden cardiac arrest, and acute myocardial infarction are the most common causes of ischemia/reperfusion injury without effective pharmacologic therapies. Existing preclinical evidence suggests that histone deacetylase inhibitors may be an efficacious, affordable, and clinically feasible therapy that can improve neurologic and cardiac outcomes following ischemia/reperfusion injury. In this review, we discuss the pathophysiology and epigenetic modulations of ischemia/reperfusion injury and focus on the neuroprotective and cardioprotective effects of histone deacetylase inhibitors. We also summarize the protective effects of histone deacetylase inhibitors for other vital organs and highlight the key research priorities for their successful translation to the bedside.
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.120.016349