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Antibodies against Borrelia burgdorferi Sensu Lato in Clinically Healthy and Sick Horses: First Report from the Czech Republic
Lyme disease, caused by some strains of bacterial spirochetes sensu lato ( sl), affects humans but also domestic animals including horses. The primary pathogens in horses in Europe are , and sensu stricto. To our knowledge, there are no data available on the seropositivity of s.l. in horses from the...
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Published in: | Microorganisms (Basel) 2023-06, Vol.11 (7), p.1706 |
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description | Lyme disease, caused by some strains of bacterial spirochetes
sensu lato (
sl), affects humans but also domestic animals including horses. The primary pathogens in horses in Europe are
,
and
sensu stricto. To our knowledge, there are no data available on the seropositivity of
s.l. in horses from the Czech Republic. In this country, horses are mainly used for sport, breeding, and recreational riding in areas where vectors of
s.l. are present, which is why they are frequently at risk of infection. The aim of the study was to detect anti-borrelia IgM and IgG antibodies in clinically healthy and sick horses from the Czech Republic and to evaluate the risk factors of infection. In total, sera of 262 horses (247 clinically healthy horses and 15 horses hospitalized due to symptoms of encephalitis/meningoencephalitis) were examined by an indirect sandwich enzyme-linked immunosorbent assay. Positivity of
was 27% (66/247) in clinically healthy horses (21% IgM, 7% IgG and 3% IgM + IgG antibodies) and 20% (3/15) in horses with clinical signs (20% IgM, 7% IgG and 7% IgM + IgG). In the clinically healthy horses, positivity statistically differed (
≤ 0.05) only in Pony and Warmblood breeds, being the most affected at 32% and 30%, respectively, while other characteristics (sex, age, usage and localities) had no effect on positivity. This is the first survey of antibodies to
s.l. in Czech horses showing that horses are exposed to ticks infected with
s.l. This should be taken into account when making differential diagnoses in patients with non-specific symptoms to start with adequate therapy. |
doi_str_mv | 10.3390/microorganisms11071706 |
format | article |
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sensu lato (
sl), affects humans but also domestic animals including horses. The primary pathogens in horses in Europe are
,
and
sensu stricto. To our knowledge, there are no data available on the seropositivity of
s.l. in horses from the Czech Republic. In this country, horses are mainly used for sport, breeding, and recreational riding in areas where vectors of
s.l. are present, which is why they are frequently at risk of infection. The aim of the study was to detect anti-borrelia IgM and IgG antibodies in clinically healthy and sick horses from the Czech Republic and to evaluate the risk factors of infection. In total, sera of 262 horses (247 clinically healthy horses and 15 horses hospitalized due to symptoms of encephalitis/meningoencephalitis) were examined by an indirect sandwich enzyme-linked immunosorbent assay. Positivity of
was 27% (66/247) in clinically healthy horses (21% IgM, 7% IgG and 3% IgM + IgG antibodies) and 20% (3/15) in horses with clinical signs (20% IgM, 7% IgG and 7% IgM + IgG). In the clinically healthy horses, positivity statistically differed (
≤ 0.05) only in Pony and Warmblood breeds, being the most affected at 32% and 30%, respectively, while other characteristics (sex, age, usage and localities) had no effect on positivity. This is the first survey of antibodies to
s.l. in Czech horses showing that horses are exposed to ticks infected with
s.l. This should be taken into account when making differential diagnoses in patients with non-specific symptoms to start with adequate therapy.</description><identifier>ISSN: 2076-2607</identifier><identifier>EISSN: 2076-2607</identifier><identifier>DOI: 10.3390/microorganisms11071706</identifier><identifier>PMID: 37512879</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antibodies ; Arachnids ; Borrelia burgdorferi ; borreliosis ; Cluster analysis ; Diagnosis ; Domestic animals ; ELISA ; Encephalitis ; Enzyme-linked immunosorbent assay ; Enzymes ; equine ; Health aspects ; Health risks ; Horses ; Identification and classification ; Immunoglobulin G ; Immunoglobulin M ; Infections ; Lyme disease ; Lyme diseases ; Measurement ; Meningitis ; Meningoencephalitis ; Physiological aspects ; Recreation areas ; Risk factors ; Signs and symptoms ; Spirochetes ; Testing ; Ticks ; Vector-borne diseases ; Vectors ; Viral antibodies</subject><ispartof>Microorganisms (Basel), 2023-06, Vol.11 (7), p.1706</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c523t-d2e8747f79645140b32d8b3c43af962b092ca9c0f472198b1978dac3040423563</cites><orcidid>0000-0003-3382-0913 ; 0000-0001-7079-5169 ; 0000-0002-9087-0880</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2843083378/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2843083378?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37512879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasparkova, Nikola</creatorcontrib><creatorcontrib>Bartova, Eva</creatorcontrib><creatorcontrib>Zakovska, Alena</creatorcontrib><creatorcontrib>Budikova, Marie</creatorcontrib><creatorcontrib>Sedlak, Kamil</creatorcontrib><title>Antibodies against Borrelia burgdorferi Sensu Lato in Clinically Healthy and Sick Horses: First Report from the Czech Republic</title><title>Microorganisms (Basel)</title><addtitle>Microorganisms</addtitle><description>Lyme disease, caused by some strains of bacterial spirochetes
sensu lato (
sl), affects humans but also domestic animals including horses. The primary pathogens in horses in Europe are
,
and
sensu stricto. To our knowledge, there are no data available on the seropositivity of
s.l. in horses from the Czech Republic. In this country, horses are mainly used for sport, breeding, and recreational riding in areas where vectors of
s.l. are present, which is why they are frequently at risk of infection. The aim of the study was to detect anti-borrelia IgM and IgG antibodies in clinically healthy and sick horses from the Czech Republic and to evaluate the risk factors of infection. In total, sera of 262 horses (247 clinically healthy horses and 15 horses hospitalized due to symptoms of encephalitis/meningoencephalitis) were examined by an indirect sandwich enzyme-linked immunosorbent assay. Positivity of
was 27% (66/247) in clinically healthy horses (21% IgM, 7% IgG and 3% IgM + IgG antibodies) and 20% (3/15) in horses with clinical signs (20% IgM, 7% IgG and 7% IgM + IgG). In the clinically healthy horses, positivity statistically differed (
≤ 0.05) only in Pony and Warmblood breeds, being the most affected at 32% and 30%, respectively, while other characteristics (sex, age, usage and localities) had no effect on positivity. This is the first survey of antibodies to
s.l. in Czech horses showing that horses are exposed to ticks infected with
s.l. This should be taken into account when making differential diagnoses in patients with non-specific symptoms to start with adequate therapy.</description><subject>Antibodies</subject><subject>Arachnids</subject><subject>Borrelia burgdorferi</subject><subject>borreliosis</subject><subject>Cluster analysis</subject><subject>Diagnosis</subject><subject>Domestic animals</subject><subject>ELISA</subject><subject>Encephalitis</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>equine</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Horses</subject><subject>Identification and classification</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Infections</subject><subject>Lyme disease</subject><subject>Lyme diseases</subject><subject>Measurement</subject><subject>Meningitis</subject><subject>Meningoencephalitis</subject><subject>Physiological aspects</subject><subject>Recreation areas</subject><subject>Risk factors</subject><subject>Signs and symptoms</subject><subject>Spirochetes</subject><subject>Testing</subject><subject>Ticks</subject><subject>Vector-borne diseases</subject><subject>Vectors</subject><subject>Viral antibodies</subject><issn>2076-2607</issn><issn>2076-2607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl1vFCEUhidGY5vav9CQeOPNVr5mAG_MurFuk01MrF4ThoFZVgYqzJisF_52mW6tXVO4gBze88A5vFV1geAlIQK-HZxOMaZeBZeHjBBkiMHmWXWKIWsWuIHs-aP9SXWe8w6WIRDhNXpZnRBWI8yZOK1-L8Po2tg5k4HqlQt5BB9iSsY7Bdop9V1M1iQHbkzIE9ioMQIXwMq74LTyfg_WRvlxuwcqdODG6e9gHVM2-R24cqnAvpjbmEZgUxzAuDVg9cvo7RydWu_0q-qFVT6b8_v1rPp29fHrar3YfP50vVpuFrrGZFx02HBGmWWioTWisCW44y3RlCgrGtxCgbUSGlrKMBK8RYLxTmkCKaSY1A05q64P3C6qnbxNblBpL6Ny8i5QeilVGp32RiqsEGkFrolllHPLG0hKK_HMKWBRWO8PrFLCYDptwpiUP4IenwS3lX38KREkvKkJLIQ394QUf0wmj3JwWRvvVTBxyhJzSiGn5YOK9PV_0l2cUii9mlUEckIY_6fqVanABRvLxXqGyiWrBaobfvfwyydUZXamOCoGY12JHyU0h4Rit5yTsQ9FIihnJ8qnnVgSLx636CHtr-_IHxD-27Y</recordid><startdate>20230629</startdate><enddate>20230629</enddate><creator>Kasparkova, Nikola</creator><creator>Bartova, Eva</creator><creator>Zakovska, Alena</creator><creator>Budikova, Marie</creator><creator>Sedlak, Kamil</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3382-0913</orcidid><orcidid>https://orcid.org/0000-0001-7079-5169</orcidid><orcidid>https://orcid.org/0000-0002-9087-0880</orcidid></search><sort><creationdate>20230629</creationdate><title>Antibodies against Borrelia burgdorferi Sensu Lato in Clinically Healthy and Sick Horses: First Report from the Czech Republic</title><author>Kasparkova, Nikola ; Bartova, Eva ; Zakovska, Alena ; Budikova, Marie ; Sedlak, Kamil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-d2e8747f79645140b32d8b3c43af962b092ca9c0f472198b1978dac3040423563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antibodies</topic><topic>Arachnids</topic><topic>Borrelia burgdorferi</topic><topic>borreliosis</topic><topic>Cluster analysis</topic><topic>Diagnosis</topic><topic>Domestic animals</topic><topic>ELISA</topic><topic>Encephalitis</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>equine</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Horses</topic><topic>Identification and classification</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>Infections</topic><topic>Lyme disease</topic><topic>Lyme diseases</topic><topic>Measurement</topic><topic>Meningitis</topic><topic>Meningoencephalitis</topic><topic>Physiological aspects</topic><topic>Recreation areas</topic><topic>Risk factors</topic><topic>Signs and symptoms</topic><topic>Spirochetes</topic><topic>Testing</topic><topic>Ticks</topic><topic>Vector-borne diseases</topic><topic>Vectors</topic><topic>Viral antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasparkova, Nikola</creatorcontrib><creatorcontrib>Bartova, Eva</creatorcontrib><creatorcontrib>Zakovska, Alena</creatorcontrib><creatorcontrib>Budikova, Marie</creatorcontrib><creatorcontrib>Sedlak, Kamil</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Biological Sciences</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Microorganisms (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasparkova, Nikola</au><au>Bartova, Eva</au><au>Zakovska, Alena</au><au>Budikova, Marie</au><au>Sedlak, Kamil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibodies against Borrelia burgdorferi Sensu Lato in Clinically Healthy and Sick Horses: First Report from the Czech Republic</atitle><jtitle>Microorganisms (Basel)</jtitle><addtitle>Microorganisms</addtitle><date>2023-06-29</date><risdate>2023</risdate><volume>11</volume><issue>7</issue><spage>1706</spage><pages>1706-</pages><issn>2076-2607</issn><eissn>2076-2607</eissn><abstract>Lyme disease, caused by some strains of bacterial spirochetes
sensu lato (
sl), affects humans but also domestic animals including horses. The primary pathogens in horses in Europe are
,
and
sensu stricto. To our knowledge, there are no data available on the seropositivity of
s.l. in horses from the Czech Republic. In this country, horses are mainly used for sport, breeding, and recreational riding in areas where vectors of
s.l. are present, which is why they are frequently at risk of infection. The aim of the study was to detect anti-borrelia IgM and IgG antibodies in clinically healthy and sick horses from the Czech Republic and to evaluate the risk factors of infection. In total, sera of 262 horses (247 clinically healthy horses and 15 horses hospitalized due to symptoms of encephalitis/meningoencephalitis) were examined by an indirect sandwich enzyme-linked immunosorbent assay. Positivity of
was 27% (66/247) in clinically healthy horses (21% IgM, 7% IgG and 3% IgM + IgG antibodies) and 20% (3/15) in horses with clinical signs (20% IgM, 7% IgG and 7% IgM + IgG). In the clinically healthy horses, positivity statistically differed (
≤ 0.05) only in Pony and Warmblood breeds, being the most affected at 32% and 30%, respectively, while other characteristics (sex, age, usage and localities) had no effect on positivity. This is the first survey of antibodies to
s.l. in Czech horses showing that horses are exposed to ticks infected with
s.l. This should be taken into account when making differential diagnoses in patients with non-specific symptoms to start with adequate therapy.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37512879</pmid><doi>10.3390/microorganisms11071706</doi><orcidid>https://orcid.org/0000-0003-3382-0913</orcidid><orcidid>https://orcid.org/0000-0001-7079-5169</orcidid><orcidid>https://orcid.org/0000-0002-9087-0880</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Antibodies Arachnids Borrelia burgdorferi borreliosis Cluster analysis Diagnosis Domestic animals ELISA Encephalitis Enzyme-linked immunosorbent assay Enzymes equine Health aspects Health risks Horses Identification and classification Immunoglobulin G Immunoglobulin M Infections Lyme disease Lyme diseases Measurement Meningitis Meningoencephalitis Physiological aspects Recreation areas Risk factors Signs and symptoms Spirochetes Testing Ticks Vector-borne diseases Vectors Viral antibodies |
title | Antibodies against Borrelia burgdorferi Sensu Lato in Clinically Healthy and Sick Horses: First Report from the Czech Republic |
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