Explication of the Potential of 2-Hydroxy-4-Methoxybenzaldehyde in Hampering Uropathogenic Proteus mirabilis Crystalline Biofilm and Virulence

is an important etiological agent of catheter-associated urinary tract infections (CAUTIs) owing to its efficient crystalline biofilm formation and virulence enzyme production. Hence, the present study explicated the antibiofilm and antivirulence efficacies of 2-hydroxy-4-methoxybenzaldehyde (HMB) a...

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Bibliographic Details
Published in:Frontiers in microbiology 2019-12, Vol.10, p.2804-2804
Main Authors: Durgadevi, Ravindran, Abirami, Gurusamy, Alexpandi, Rajaiah, Nandhini, Kumar, Kumar, Ponnuchamy, Prakash, Santhiyagu, Veera Ravi, Arumugam
Format: Article
Language:English
Subjects:
2-hydroxy-4-methoxybenzaldehyde
antivirulence
biofilm inhibition
crystalline biofilm
Microbiology
Proteus mirabilis
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Summary:is an important etiological agent of catheter-associated urinary tract infections (CAUTIs) owing to its efficient crystalline biofilm formation and virulence enzyme production. Hence, the present study explicated the antibiofilm and antivirulence efficacies of 2-hydroxy-4-methoxybenzaldehyde (HMB) against in a non-bactericidal manner. HMB showed concentration-dependent biofilm inhibition, which was also evinced in light, confocal, and scanning electron microscopic (SEM) analyses. The other virulence factors such as urease, hemolysin, siderophores, and extracellular polymeric substances production as well as swimming and swarming motility were also inhibited by HMB treatment. Further, HMB treatment effectively reduced the struvite/apatite production as well as crystalline biofilm formation by . Furthermore, the results of gene expression analysis unveiled the ability of HMB to impair the expression level of virulence genes such as , , , , , , and , which was found to be in correlation with the results of bioassays. Additionally, the cytotoxicity analysis divulged the innocuous characteristic of HMB against human embryonic kidney cells. Thus, the present study reports the potency of HMB to act as a promising therapeutic remedy for -instigated CAUTIs.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2019.02804