Gonadotrophin releasing hormone antagonist in IVF/ICSI

To study the efficacy of gonadotrophin releasing hormone (GnRH) antagonist in In-vitro-fertilization/Intracytoplasmic sperm injection (IVF/ICSI) cycles. Observational study. Reproductive Medicine Unit, Christian Medical College Hospital, Vellore, Tamil Nadu. GnRH antagonists were introduced into our...

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Bibliographic Details
Published in:Journal of human reproductive sciences 2008-01, Vol.1 (1), p.29-32
Main Authors: Ms, Kamath, Am, Mangalraj, Km, Muthukumar, K, George
Format: Article
Language:English
Subjects:
Antagonists
Assisted reproduction
Embryos
Estrogen
Fertilization in vitro
Gonadotrophin releasing hormone antagonists
Health aspects
ICSI
IVF
Methods
Original
Pituitary gland
Pregnancy
Reproductive health
Reproductive technologies
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Summary:To study the efficacy of gonadotrophin releasing hormone (GnRH) antagonist in In-vitro-fertilization/Intracytoplasmic sperm injection (IVF/ICSI) cycles. Observational study. Reproductive Medicine Unit, Christian Medical College Hospital, Vellore, Tamil Nadu. GnRH antagonists were introduced into our practice in November 2005. Fifty-two women undergoing the antagonist protocol were studied and information gathered regarding patient profile, treatment parameters (total gonadotrophin dosage, duration of treatment, and oocyte yield), and outcomes in terms of embryological parameters (cleavage rates, implantation rates) and clinical pregnancy. These parameters were compared with 121 women undergoing the standard long protocol. The costs between the two groups were also compared. Clinical pregnancy rate. The clinical pregnancy rate per embryo transfer in the antagonist group was 31.7% which was comparable to the clinical pregnancy rate in women undergoing the standard long protocol (30.63%). The costs between the two groups were comparable. GnRH antagonist protocol was found to be effective and comparable to the standard long protocol regimen. In addition it was simple, convenient, and patient friendly.
ISSN:0974-1208
1998-4766
DOI:10.4103/0974-1208.39594