ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEW

Periodontitis, a chronic inflammatory disease of oral cavity, caused by the complex interactions between host immune system and sub-gingival microbiota leading to chronic gingival inflammation, loss of periodontal ligament attachment, dental impairment, and finally tooth loss. Prevalence of periodon...

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Bibliographic Details
Published in:Khyber Medical University journal 2020-10, Vol.12 (4), p.326-30
Main Authors: Hamda Shazam, Fouzia Shaikh, Muhammad Mansoor Majeed, Sadia Khan, Saba Khan
Format: Article
Language:English
Subjects:
biomarker
cytokines
diagnosis
gingivitis
growth factors
matrix metalloproteinases
osteocalcin
periodontitis
saliva
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Summary:Periodontitis, a chronic inflammatory disease of oral cavity, caused by the complex interactions between host immune system and sub-gingival microbiota leading to chronic gingival inflammation, loss of periodontal ligament attachment, dental impairment, and finally tooth loss. Prevalence of periodontal disease varies and reported a higher prevalence in Asian countries. The conventional diagnostic techniques used for periodontitis are inherently limited. Periodontitis immunopathogenesis studies and mediator analyzes in saliva allowed the identification of a number of disease-specific molecular biomarkers. In this review article, diagnostic role of various salivary biomarkers in periodontitis has been discussed. Original articles, systematic and narrative reviews related to relevant study, published since 2009-2019 were included in the literature search through PubMed, Google Scholar, Web of Science and Scopus. Convenient assessments of these salivary biomarkers with analytical chair facilities will yield more accurate diagnostic results which will further aid in early detection and better clinical management of periodontitis patients.
ISSN:2305-2643
2305-2651
DOI:10.35845/kmuj.2020.19808