RELATIONSHIP BETWEEN DETECTION OF TB AND TREATMENT OF MDR/XDR TB

• Published in: International journal of infectious diseases 2023-08, Vol.134, p.S3
• Main Authors: Guseva, V., Otpushchennikova, O., Doktorova, N., Lizinfeld, I., Parolina, L., Samoylova, A.
• Format: Article
• Language: English
• ISSN: 1201-9712
• DOI: 10.1016/j.ijid.2023.05.025

Intro: Increasing the effectiveness of treatment of patients with multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) is an important public health objective. The factors that have a direct impact on the results of treatment of patients with MDR/XDR-TB are well studied: late diagnosis of drug resistance, various problems of chemotherapy, and comorbidities. Factors that may indirectly influence the effectiveness of MDR/XDR TB chemotherapy are not well understood. Aim: To analyze the relationship between the active TB detection methods and the effectiveness of the MDR/XDR-TB treatment. Methods: Correlation analysis of the relationship between the detection of pulmonary TB by fluorography, skin immunological tests, and bacterioscopy with effective outcomes of chemotherapy in in MDR/XDR-TB patients in 85 regions of Russia over 8 years was carried out using the Spearman coefficient. Using the method of linear regression, a predictive model was developed that characterizes the link between various screening methods and the treatment effectiveness. Findings: Statistically significant direct correlations were obtained between the effective treatment of MDR/XDR-TB and the methods of active detection of pulmonary TB: with fluorography (ρ=0.898; p