A green, facile, and practical preparation of capsaicin derivatives with thiourea structure

Capsaicin derivatives with thiourea structure (CDTS) is highly noteworthy owing to its higher analgesic potency in rodent models and higher agonism in vitro. However, the direct synthesis of CDTS remains t one or more shortcomings. In this study, we present reported a green, facile, and practical sy...

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Bibliographic Details
Published in:Scientific reports 2024-05, Vol.14 (1), p.10576-10576, Article 10576
Main Authors: Chen, Lina, Gao, Zhenhua, Zhang, Ye, Dai, Xiandong, Meng, Fanhua, Guo, Yongbiao
Format: Article
Language:English
Subjects:
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Analgesics
Animal models
Animals
Automation
Capsaicin
Capsaicin - chemistry
Green Chemistry Technology - methods
Humanities and Social Sciences
Hydrocarbons
Molecular Structure
multidisciplinary
Science
Science (multidisciplinary)
Solvents
Thiourea
Thiourea - chemistry
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Summary:Capsaicin derivatives with thiourea structure (CDTS) is highly noteworthy owing to its higher analgesic potency in rodent models and higher agonism in vitro. However, the direct synthesis of CDTS remains t one or more shortcomings. In this study, we present reported a green, facile, and practical synthetic method of capsaicin derivatives with thiourea structure is developed by using an automated synthetic system, leading to a series of capsaicin derivatives with various electronic properties and functionalities in good to excellent yields.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-61014-5