Serum Trace Elements and Their Associations with Breast Cancer Subgroups in Korean Breast Cancer Patients

The relationships between serum levels of trace elements and breast cancer remain relatively unknown. In this study, we investigate serum levels of seven trace elements in Korean breast cancer patients compared to controls without breast cancer. Serum trace element levels were determined using induc...

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Bibliographic Details
Published in:Nutrients 2018-12, Vol.11 (1), p.37
Main Authors: Choi, Rihwa, Kim, Min-Ji, Sohn, Insuk, Kim, Serim, Kim, Isaac, Ryu, Jai Min, Choi, Hee Jun, Kim, Jae-Myung, Lee, Se Kyung, Yu, Jonghan, Kim, Seok Won, Nam, Seok Jin, Lee, Jeong Eon, Lee, Soo-Youn
Format: Article
Language:English
Subjects:
Breast cancer
Cancer therapies
Females
Health risk assessment
Laboratories
manganese
Metastases
molybdenum
Serum levels
Studies
Subgroups
Trace elements
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Summary:The relationships between serum levels of trace elements and breast cancer remain relatively unknown. In this study, we investigate serum levels of seven trace elements in Korean breast cancer patients compared to controls without breast cancer. Serum trace element levels were determined using inductively coupled plasma mass spectrometry in Korean breast cancer patients before initiation of breast cancer treatment. Korean females without breast cancer served as a control group. Trace element levels were measured in the discovery cohort ( = 287) and were validated in an independent cohort ( = 142). We further investigated possible associations between trace element levels and the presence of lymph node metastasis, distant metastasis, or triple-negative breast cancer among breast cancer patients in subgroup analyses. Serum manganese and molybdenum levels were significantly higher ( < 0.05) in breast cancer patients than in controls. Serum copper levels were significantly higher in breast cancer patients with distant metastasis, while selenium levels were significantly lower. Other trace elements were neither significantly different between breast cancer patients and controls nor between subgroups of breast cancer patients. Our study provides insights about the potential roles and impacts of trace elements through an assessment of the associations between trace elements and breast cancer.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu11010037