Rotavirus infection and the current status of rotavirus vaccines

Among children, rotaviruses are the most common cause of severe gastroenteritis worldwide and of diarrheal deaths in developing countries. Current vaccines (e.g., Rotarix, GlaxoSmithKline Biologicals; RotaTeq, Merck and Company) effectively reduce rotaviral gastroenteritis, emergency department visi...

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Bibliographic Details
Published in:Journal of the Formosan Medical Association 2012-04, Vol.111 (4), p.183-193
Main Authors: Chen, Shou-Chien, Tan, Lia-Beng, Huang, Li-Min, Chen, Kow-Tong
Format: Article
Language:English
Subjects:
epidemiology
gastroenteritis
Gastroenteritis - economics
Gastroenteritis - epidemiology
Gastroenteritis - prevention & control
Gastroenteritis - virology
Humans
Internal Medicine
Rotavirus
Rotavirus - immunology
Rotavirus Infections - economics
Rotavirus Infections - epidemiology
Rotavirus Infections - prevention & control
Rotavirus Infections - virology
rotavirus vaccine
Rotavirus Vaccines - adverse effects
Rotavirus Vaccines - immunology
Vaccines, Attenuated - adverse effects
Vaccines, Attenuated - immunology
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Summary:Among children, rotaviruses are the most common cause of severe gastroenteritis worldwide and of diarrheal deaths in developing countries. Current vaccines (e.g., Rotarix, GlaxoSmithKline Biologicals; RotaTeq, Merck and Company) effectively reduce rotaviral gastroenteritis, emergency department visits, and hospitalizations. The tremendous burden of rotavirus-related diarrhea in children across the world continues to drive the remarkable pace of vaccine development. This review assesses the global epidemiological and economic burden of rotavirus diseases, summarizes the relevant principles of the development of rotavirus vaccines, and presents data on the efficacy and effectiveness of currently licensed vaccines in both developed and developing countries.
ISSN:0929-6646
DOI:10.1016/j.jfma.2011.09.024