HDL-C to hsCRP ratio is associated with left ventricular diastolic function in absence of significant coronary atherosclerosis

• Published in: Lipids in health and disease 2019-12, Vol.18 (1), p.219-219, Article 219
• Main Authors: Sun, Lufan, Liu, Xiaorui, Li, Wenna, Jia, Dalin
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Aged, 80 and over; Analysis; Angiography; Arteriosclerosis; Atherosclerosis; Blood pressure; C-reactive protein; C-Reactive Protein - analysis; Cardiac patients; Cardiology; Cardiovascular disease; Cardiovascular risk factor; CAT scans; Chest Pain; Cholesterol; Cholesterol, HDL - blood; Computed tomography; Congestive heart failure; Coronary artery; Coronary Artery Disease - diagnosis; Coronary vessels; Diabetes; Echocardiography; Fasting; Female; Flow velocity; Heart; Heart failure; High density lipoprotein; High-density lipoprotein cholesterol; Hospitals; Humans; Hypertension; Inflammation; Ischemia; Laboratories; Left ventricular diastolic function; Lipoproteins; Male; Medical imaging; Middle Aged; Multiple regression analysis; Plaques; Plasma; Regression analysis; Risk Factors; Sensitivity and Specificity; Statistical analysis; Variance analysis; Veins & arteries; Ventricle; Ventricular Dysfunction, Left - blood; Ventricular Function, Left
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-019-1157-6

High-density lipoprotein cholesterol (HDL-C) is considered as a protective marker of coronary atherosclerotic disease (CAD). It is still not clear if HDL-C is associated with left ventricular (LV) diastolic function in an inflammation-related manner in absence of significant coronary atherosclerosis. 392 patients who complained of chest pain and were suspected of CAD without heart failure were enrolled in this study. Coronary angiography or coronary artery CT scan was performed to detect coronary atherosclerosis. Transthoracic echocardiography was performed to evaluate cardiac function. Plasma level of HDL-C and high-sensitive C-reactive protein (hsCRP) were determined in each subject. Relationship between HDL-C/hsCRP ratio and LV diastolic function in subjects without significant coronary atherosclerosis was investigated. 204 subjects without significant coronary plaques were analyzed finally, including 84 males and 120 females whose ages ranged from 30 to 84 years old. When divided into HDL-C/hsCRP quartiles, those in the fourth quartile demonstrated the best diastolic function (E/e' 10.14 ± 2.87, P = 0.02 ). HDL-C/hsCRP was the most significant factor correlated with E/e' in univariate regression analysis (r = - 0.232, P