Synthesis, Characterization and DNA Binding Investigations of a New Binuclear Ag(I) Complex and Evaluation of Its Anticancer Property

A new Ag(I) complex (A ) was synthesized and evaluated for its anticancer activity against human cancer cell lines. The complex A was characterized by H, C, and P nuclear magnetic resonance (NMR), infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complex wi...

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Bibliographic Details
Published in:International journal of nanomedicine 2020-01, Vol.15, p.953-964
Main Authors: Zheng, Mian-Hong, Bigdeli, Fahime, Gao, Lan-Xing, Wu, Deng-Ze, Yan, Xiao-Wei, Hu, Mao-Lin, Morsali, Ali
Format: Article
Language:English
Subjects:
anticancer
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Binding sites
binuclear ag(i) complex
Biological activity
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Cancer
Cancer cells
Cancer metastasis
Cancer therapies
Cancer treatment
CAT scans
Cell cycle
Cell Line, Tumor
Cell Survival - drug effects
Characterization
Chemotherapy
Colorectal cancer
Coordination Complexes - chemistry
Coordination Complexes - metabolism
Crystallography, X-Ray
Deoxyribonucleic acid
Diagnostic imaging
DNA
DNA - chemistry
DNA - metabolism
DNA binding
Electrodes
electrostatic binding
Female
Fluorescence
Fluorescence spectroscopy
HCT116 Cells
Humans
Hydrochloric acid
Investigations
Ligands
Magnetic Resonance Spectroscopy
Metals
Molecular Structure
NMR
Nuclear magnetic resonance
Original Research
Silver
Silver - chemistry
Silver - pharmacology
Spectrometry, Fluorescence
Spectroscopy
Spectrum analysis
x-ray crystallography
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Description
Summary:A new Ag(I) complex (A ) was synthesized and evaluated for its anticancer activity against human cancer cell lines. The complex A was characterized by H, C, and P nuclear magnetic resonance (NMR), infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complex with CT-DNA was studied by electronic absorption spectra, fluorescence spectroscopy, and cyclic voltammetry; cell viability (%) was assessed by absorbance measurement of the samples. The interaction mode of the complex A with DNA is electrostatic, and this complex shows good potential in anticancer properties against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with 0.5 micromolar concentrations. The Ag(I) complex could interact with DNA noncovalently and has anticancer properties.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S225038