The New Kid on the Block: Online Adaptive Radiotherapy in the Treatment of Gynecologic Cancers

Online adaptive radiation is a new and exciting modality of treatment for gynecologic cancers. Traditional radiation treatments deliver the same radiation plan to cancers with large margins. Improvements in imaging, technology, and artificial intelligence have made it possible to account for changes...

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Bibliographic Details
Published in:Current oncology (Toronto) 2023-01, Vol.30 (1), p.865-874
Main Authors: Yen, Allen, Shen, Chenyang, Albuquerque, Kevin
Format: Article
Language:English
Subjects:
Artificial Intelligence
Female
gynecologic cancer
Humans
online adaptive radiotherapy
Organs at Risk - pathology
radiation oncology
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Image-Guided - methods
Review
Urinary Bladder Neoplasms
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Summary:Online adaptive radiation is a new and exciting modality of treatment for gynecologic cancers. Traditional radiation treatments deliver the same radiation plan to cancers with large margins. Improvements in imaging, technology, and artificial intelligence have made it possible to account for changes between treatments and improve the delivery of radiation. These advances can potentially lead to significant benefits in tumor coverage and normal tissue sparing. Gynecologic cancers can uniquely benefit from this technology due to the significant changes in bladder, bowel, and rectum between treatments as well as the changes in tumors commonly seen between treatments. Preliminary studies have shown that online adaptive radiation can maintain coverage of the tumor while sparing nearby organs. Given these potential benefits, numerous clinical trials are ongoing to investigate the clinical benefits of online adaptive radiotherapy. Despite the benefits, implementation of online adaptive radiotherapy requires significant clinical resources. Additionally, the timing and workflow for online adaptive radiotherapy is being optimized. In this review, we discuss the history and evolution of radiation techniques, the logistics and implementation of online adaptive radiation, and the potential benefits of online adaptive radiotherapy for gynecologic cancers.
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol30010066