Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes

Malaria parasite erythrocytic stages comprise of repeated bursts of parasites via cyclical invasion of host erythrocytes using dedicated receptor-ligand interactions. A family of erythrocyte-binding proteins from ( ) and ( ) attach to human Duffy antigen receptor for chemokines (DARC) via their Duff...

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Bibliographic Details
Published in:Frontiers in molecular biosciences 2018-08, Vol.5, p.78-78
Main Authors: Yogavel, Manickam, Chhibber-Goel, Jyoti, Jamwal, Abhishek, Gupta, Swati, Sharma, Amit
Format: Article
Language:English
Subjects:
Duffy antigen receptor for chemokines (DARC)
Duffy binding-like domains (DBLs)
malaria
Molecular Biosciences
Plasmodium
Structure
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Summary:Malaria parasite erythrocytic stages comprise of repeated bursts of parasites via cyclical invasion of host erythrocytes using dedicated receptor-ligand interactions. A family of erythrocyte-binding proteins from ( ) and ( ) attach to human Duffy antigen receptor for chemokines (DARC) via their Duffy binding-like domains (DBLs) for invasion. Here we provide a novel, testable and overarching interaction model that rationalizes even contradictory pieces of evidence that have so far existed in the literature on / -DBL/DARC binding determinants. We further address the conundrum of how parasite-encoded / -DBLs recognize human DARC and collate evidence for two distinct DARC integration sites on / -DBLs.
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2018.00078