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Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes
Malaria parasite erythrocytic stages comprise of repeated bursts of parasites via cyclical invasion of host erythrocytes using dedicated receptor-ligand interactions. A family of erythrocyte-binding proteins from ( ) and ( ) attach to human Duffy antigen receptor for chemokines (DARC) via their Duff...
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| Published in: | Frontiers in molecular biosciences 2018-08, Vol.5, p.78-78 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 78 |
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| container_start_page | 78 |
| container_title | Frontiers in molecular biosciences |
| container_volume | 5 |
| creator | Yogavel, Manickam Chhibber-Goel, Jyoti Jamwal, Abhishek Gupta, Swati Sharma, Amit |
| description | Malaria parasite erythrocytic stages comprise of repeated bursts of parasites via cyclical invasion of host erythrocytes using dedicated receptor-ligand interactions. A family of erythrocyte-binding proteins from
(
) and
(
) attach to human Duffy antigen receptor for chemokines (DARC) via their Duffy binding-like domains (DBLs) for invasion. Here we provide a novel, testable and overarching interaction model that rationalizes even contradictory pieces of evidence that have so far existed in the literature on
/
-DBL/DARC binding determinants. We further address the conundrum of how parasite-encoded
/
-DBLs recognize human DARC and collate evidence for two distinct DARC integration sites on
/
-DBLs. |
| doi_str_mv | 10.3389/fmolb.2018.00078 |
| format | article |
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(
) and
(
) attach to human Duffy antigen receptor for chemokines (DARC) via their Duffy binding-like domains (DBLs) for invasion. Here we provide a novel, testable and overarching interaction model that rationalizes even contradictory pieces of evidence that have so far existed in the literature on
/
-DBL/DARC binding determinants. We further address the conundrum of how parasite-encoded
/
-DBLs recognize human DARC and collate evidence for two distinct DARC integration sites on
/
-DBLs.</description><identifier>ISSN: 2296-889X</identifier><identifier>EISSN: 2296-889X</identifier><identifier>DOI: 10.3389/fmolb.2018.00078</identifier><identifier>PMID: 30211170</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>Duffy antigen receptor for chemokines (DARC) ; Duffy binding-like domains (DBLs) ; malaria ; Molecular Biosciences ; Plasmodium ; Structure</subject><ispartof>Frontiers in molecular biosciences, 2018-08, Vol.5, p.78-78</ispartof><rights>Copyright © 2018 Yogavel, Chhibber-Goel, Jamwal, Gupta and Sharma. 2018 Yogavel, Chhibber-Goel, Jamwal, Gupta and Sharma</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-1b5f40f04c7c0ef94593476def5a1344351bfaef6534f4be79473db46b054e0d3</citedby><cites>FETCH-LOGICAL-c462t-1b5f40f04c7c0ef94593476def5a1344351bfaef6534f4be79473db46b054e0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120517/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120517/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30211170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yogavel, Manickam</creatorcontrib><creatorcontrib>Chhibber-Goel, Jyoti</creatorcontrib><creatorcontrib>Jamwal, Abhishek</creatorcontrib><creatorcontrib>Gupta, Swati</creatorcontrib><creatorcontrib>Sharma, Amit</creatorcontrib><title>Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes</title><title>Frontiers in molecular biosciences</title><addtitle>Front Mol Biosci</addtitle><description>Malaria parasite erythrocytic stages comprise of repeated bursts of parasites via cyclical invasion of host erythrocytes using dedicated receptor-ligand interactions. A family of erythrocyte-binding proteins from
(
) and
(
) attach to human Duffy antigen receptor for chemokines (DARC) via their Duffy binding-like domains (DBLs) for invasion. Here we provide a novel, testable and overarching interaction model that rationalizes even contradictory pieces of evidence that have so far existed in the literature on
/
-DBL/DARC binding determinants. We further address the conundrum of how parasite-encoded
/
-DBLs recognize human DARC and collate evidence for two distinct DARC integration sites on
/
-DBLs.</description><subject>Duffy antigen receptor for chemokines (DARC)</subject><subject>Duffy binding-like domains (DBLs)</subject><subject>malaria</subject><subject>Molecular Biosciences</subject><subject>Plasmodium</subject><subject>Structure</subject><issn>2296-889X</issn><issn>2296-889X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVksFv0zAUxiMEYtPYnRPykUuKHTtxckEaXWGVKoGmTeJm2c5z6pHYxU46eucPx23H1J1sff7e7z35fVn2nuAZpXXzyQy-V7MCk3qGMeb1q-y8KJoqr-vm5-uT-1l2GeNDspASU16xt9kZxQUhhOPz7O_CdbKDAdyIbqceIrpbyxHduxbCxjp0_WWVX1_dztHSjRCkHq13ERkfktAFiBF5g370Mg6-tdOAfjn_mCgWSdee6lu7lX_2EI9upkE6tAi7cR283o0Q32VvjOwjXD6dF9n918Xd_CZfff-2nF-tcs2qYsyJKg3DBjPNNQbTsLKhjFctmFISyhgtiTISTFVSZpgC3jBOW8UqhUsGuKUX2fLIbb18EJtgBxl2wksrDoIPnZBhtLoHISluC1UZDoSwRktlFOhaykKRNEJJE-vzkbWZ1ACtTh8YZP8C-vLF2bXo_FZUpMAl4Qnw8QkQ_O8J4igGGzX0vXTgpygKgmnF67SzZMVHqw4-xgDmuQ3BYp8FcciC2GdBHLKQSj6cjvdc8H_z9B8gJLOj</recordid><startdate>20180827</startdate><enddate>20180827</enddate><creator>Yogavel, Manickam</creator><creator>Chhibber-Goel, Jyoti</creator><creator>Jamwal, Abhishek</creator><creator>Gupta, Swati</creator><creator>Sharma, Amit</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20180827</creationdate><title>Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes</title><author>Yogavel, Manickam ; Chhibber-Goel, Jyoti ; Jamwal, Abhishek ; Gupta, Swati ; Sharma, Amit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-1b5f40f04c7c0ef94593476def5a1344351bfaef6534f4be79473db46b054e0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Duffy antigen receptor for chemokines (DARC)</topic><topic>Duffy binding-like domains (DBLs)</topic><topic>malaria</topic><topic>Molecular Biosciences</topic><topic>Plasmodium</topic><topic>Structure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yogavel, Manickam</creatorcontrib><creatorcontrib>Chhibber-Goel, Jyoti</creatorcontrib><creatorcontrib>Jamwal, Abhishek</creatorcontrib><creatorcontrib>Gupta, Swati</creatorcontrib><creatorcontrib>Sharma, Amit</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in molecular biosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yogavel, Manickam</au><au>Chhibber-Goel, Jyoti</au><au>Jamwal, Abhishek</au><au>Gupta, Swati</au><au>Sharma, Amit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes</atitle><jtitle>Frontiers in molecular biosciences</jtitle><addtitle>Front Mol Biosci</addtitle><date>2018-08-27</date><risdate>2018</risdate><volume>5</volume><spage>78</spage><epage>78</epage><pages>78-78</pages><issn>2296-889X</issn><eissn>2296-889X</eissn><abstract>Malaria parasite erythrocytic stages comprise of repeated bursts of parasites via cyclical invasion of host erythrocytes using dedicated receptor-ligand interactions. A family of erythrocyte-binding proteins from
(
) and
(
) attach to human Duffy antigen receptor for chemokines (DARC) via their Duffy binding-like domains (DBLs) for invasion. Here we provide a novel, testable and overarching interaction model that rationalizes even contradictory pieces of evidence that have so far existed in the literature on
/
-DBL/DARC binding determinants. We further address the conundrum of how parasite-encoded
/
-DBLs recognize human DARC and collate evidence for two distinct DARC integration sites on
/
-DBLs.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>30211170</pmid><doi>10.3389/fmolb.2018.00078</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | PubMed Central |
| subjects | Duffy antigen receptor for chemokines (DARC) Duffy binding-like domains (DBLs) malaria Molecular Biosciences Plasmodium Structure |
| title | Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes |
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