Platelets and Neurodegenerative Diseases: Current Knowledge and Future Perspectives

Platelets have a fundamental role in mediating hemostasis and thrombosis. However, more recently, a new idea is making headway, highlighting the importance of platelets as significant actors in modulating immune and inflammatory responses. In particular, platelets have an important role in the devel...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-06, Vol.25 (12), p.6292
Main Authors: Gallo, Antonella, Lipari, Alice, Di Francesco, Silvino, Ianuà, Eleonora, Liperoti, Rosa, Cipriani, Maria Camilla, Martone, Anna Maria, De Candia, Erica, Landi, Francesco, Montalto, Massimo
Format: Article
Language:English
Subjects:
Adenosine
Advertising executives
Aging
Alzheimer Disease - metabolism
Alzheimer's disease
Alzheimer’s
amyloid
Amyloid beta-Peptides - metabolism
Animals
Atherosclerosis
Biomarkers
Blood clot
Blood Platelets - metabolism
Clopidogrel
Cognition & reasoning
Cognitive ability
Cognitive Dysfunction - metabolism
cognitive impairment
Dementia
Development and progression
Disease
Glycoproteins
Humans
Memory
Nervous system diseases
Neurodegenerative Diseases - metabolism
Pathogenesis
Patients
Peptides
Platelet Activation
Platelet Aggregation Inhibitors - therapeutic use
platelets
Proteins
Review
Thrombosis
Tirofiban
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Summary:Platelets have a fundamental role in mediating hemostasis and thrombosis. However, more recently, a new idea is making headway, highlighting the importance of platelets as significant actors in modulating immune and inflammatory responses. In particular, platelets have an important role in the development of vascular amyloid-b-peptide(ab) deposits, known to play a relevant role in Alzheimer's disease (AD) through accumulation and deposition within the frontal cortex and hippocampus in the brain. The involvement of platelets in the pathogenesis of AD opens up the highly attractive possibility of applying antiplatelet therapy for the treatment and/or prevention of AD, but conclusive results are scarce. Even less is known about the potential role of platelets in mild cognitive impairment (MCI). The aim to this brief review is to summarize current knowledge on this topic and to introduce the new perspectives on the possible role of platelet activation as therapeutic target both in AD and MCI.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25126292