The Role of Oxidative Stress and Inflammatory Parameters in Heart Failure

Heart failure (HF) remains a major medical and social problem. The NT-pro-brain natriuretic peptide (NT-proBNP) and its active form, brain-type natriuretic peptide (BNP), in a simple blood test are the gold-standard biomarkers for HF diagnosis. However, even good biomarkers such as natriuretic pepti...

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Published in:Medicina (Kaunas, Lithuania) Lithuania), 2024-05, Vol.60 (5), p.760
Main Authors: Wróbel-Nowicka, Karolina, Wojciechowska, Celina, Jacheć, Wojciech, Zalewska, Marzena, Romuk, Ewa
Format: Article
Language:English
Subjects:
Apoptosis
biomarkers
Biomarkers - analysis
Biomarkers - blood
Blood
Canada
Cardiomyocytes
Chronic illnesses
Clinical medicine
Cytokines
Enzymes
Health aspects
Heart failure
Heart Failure - blood
Heart Failure - physiopathology
Homeostasis
Humans
Hypertension
Hypoxia
Inflammation
Inflammation - blood
Ischemia
Kinases
Medical examination
Medical prognosis
Metabolism
Mitochondria
Mitochondrial DNA
Mortality
Natriuretic Peptide, Brain - blood
Natriuretic peptides
Oxidative stress
Oxidative Stress - physiology
Pathophysiology
Peptide Fragments - blood
Peptides
Poland
Prognosis
Proteins
Social aspects
Tumor necrosis factor-TNF
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Summary:Heart failure (HF) remains a major medical and social problem. The NT-pro-brain natriuretic peptide (NT-proBNP) and its active form, brain-type natriuretic peptide (BNP), in a simple blood test are the gold-standard biomarkers for HF diagnosis. However, even good biomarkers such as natriuretic peptides fail to predict all the risks associated with HF due to the diversity of the mechanisms involved. The pathophysiology of HF is determined by numerous factors, including oxidative stress, inflammation, neuroendocrine activation, pathological angiogenesis, changes in apoptotic pathways, fibrosis and vascular remodeling. High readmission and mortality rates prompt a search for new markers for the diagnosis, prognosis and treatment of HF. Oxidative-stress-mediated inflammation plays a crucial role in the development of subsequent changes in the failing heart and provides a new insight into this complex mechanism. Oxidative stress and inflammatory biomarkers appear to be a promising diagnostic and prognostic tool in patients with HF. This systematic review provides an overview of the current knowledge about oxidative stress and inflammation parameters as markers of HF.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina60050760