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Feasibility and Efficacy of Morning Light Therapy for Adults with Insomnia: A Pilot, Randomized, Open-Label, Two-Arm Study
Light therapy (LT) is used as an adjunctive treatment for sleep problems. This study evaluates the impact of LT on sleep quality and sleep-related parameters in patients with sleep disorders. We performed a pilot, randomized, open-label clinical trial. Fourteen patients aged 20-60 years with insomni...
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| Published in: | Medicina (Kaunas, Lithuania) Lithuania), 2023-06, Vol.59 (6), p.1066 |
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| container_issue | 6 |
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| container_title | Medicina (Kaunas, Lithuania) |
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| creator | Yoon, Jihyun Heo, Seokjae Lee, Hyangkyu Sul, Eungyeong Han, Taehwa Kwon, Yu-Jin |
| description | Light therapy (LT) is used as an adjunctive treatment for sleep problems. This study evaluates the impact of LT on sleep quality and sleep-related parameters in patients with sleep disorders.
We performed a pilot, randomized, open-label clinical trial. Fourteen patients aged 20-60 years with insomnia were randomized into the control and LT groups (1:1 ratio). The LT group was instructed to use a device that provides bright LT (6000 K, 380 lux, wavelength 480 nm) for at least 25 min before 09:00 a.m. for two weeks. A self-reported questionnaire was used to evaluate circadian preference, mood, and sleep-related parameters. We analyzed serum cortisol levels and clock genes' expression.
The Epworth Sleepiness Scale (ESS), insomnia severity index(ISI), and Pittsburgh Sleep Quality index(PSQI) were significantly improved within the LT group only after the two-week period. When comparing the two groups, only the change in ESS was significant (mean difference, control: -0.14 vs. LT: -1.43,
= 0.021) after adjusting for the baseline characteristics. There were no significant differences in serum cortisol or clock genes' expression.
LT can improve daytime sleepiness in patients with sleep disorders; however, further well-designed studies are warranted to confirm its efficacy. |
| doi_str_mv | 10.3390/medicina59061066 |
| format | article |
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We performed a pilot, randomized, open-label clinical trial. Fourteen patients aged 20-60 years with insomnia were randomized into the control and LT groups (1:1 ratio). The LT group was instructed to use a device that provides bright LT (6000 K, 380 lux, wavelength 480 nm) for at least 25 min before 09:00 a.m. for two weeks. A self-reported questionnaire was used to evaluate circadian preference, mood, and sleep-related parameters. We analyzed serum cortisol levels and clock genes' expression.
The Epworth Sleepiness Scale (ESS), insomnia severity index(ISI), and Pittsburgh Sleep Quality index(PSQI) were significantly improved within the LT group only after the two-week period. When comparing the two groups, only the change in ESS was significant (mean difference, control: -0.14 vs. LT: -1.43,
= 0.021) after adjusting for the baseline characteristics. There were no significant differences in serum cortisol or clock genes' expression.
LT can improve daytime sleepiness in patients with sleep disorders; however, further well-designed studies are warranted to confirm its efficacy.</description><identifier>ISSN: 1648-9144</identifier><identifier>ISSN: 1010-660X</identifier><identifier>EISSN: 1648-9144</identifier><identifier>DOI: 10.3390/medicina59061066</identifier><identifier>PMID: 37374270</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adults ; Blood pressure ; Care and treatment ; Cholesterol ; Circadian rhythm ; Clinical trials ; clock genes ; daytime sleepiness ; Diabetes ; Ethylenediaminetetraacetic acid ; High density lipoprotein ; Homeostasis ; Hospitals ; Hypertension ; Immunoassay ; Insomnia ; Insulin ; Light ; Light therapy ; Lipoproteins ; Mental disorders ; Metabolic disorders ; Phototherapy ; Sleep apnea ; sleep disorder ; Sleep disorders</subject><ispartof>Medicina (Kaunas, Lithuania), 2023-06, Vol.59 (6), p.1066</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c511t-7f4ec3a3596205edcfa8e7f76ba9f3ccb714bc0c10f8272b16744887a8e09e1c3</cites><orcidid>0000-0002-9021-3856 ; 0000-0002-7328-7765 ; 0000-0002-0821-6020 ; 0000-0002-8764-7995 ; 0000-0002-1057-2235</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2829836489/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2829836489?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37374270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, Jihyun</creatorcontrib><creatorcontrib>Heo, Seokjae</creatorcontrib><creatorcontrib>Lee, Hyangkyu</creatorcontrib><creatorcontrib>Sul, Eungyeong</creatorcontrib><creatorcontrib>Han, Taehwa</creatorcontrib><creatorcontrib>Kwon, Yu-Jin</creatorcontrib><title>Feasibility and Efficacy of Morning Light Therapy for Adults with Insomnia: A Pilot, Randomized, Open-Label, Two-Arm Study</title><title>Medicina (Kaunas, Lithuania)</title><addtitle>Medicina (Kaunas)</addtitle><description>Light therapy (LT) is used as an adjunctive treatment for sleep problems. This study evaluates the impact of LT on sleep quality and sleep-related parameters in patients with sleep disorders.
We performed a pilot, randomized, open-label clinical trial. Fourteen patients aged 20-60 years with insomnia were randomized into the control and LT groups (1:1 ratio). The LT group was instructed to use a device that provides bright LT (6000 K, 380 lux, wavelength 480 nm) for at least 25 min before 09:00 a.m. for two weeks. A self-reported questionnaire was used to evaluate circadian preference, mood, and sleep-related parameters. We analyzed serum cortisol levels and clock genes' expression.
The Epworth Sleepiness Scale (ESS), insomnia severity index(ISI), and Pittsburgh Sleep Quality index(PSQI) were significantly improved within the LT group only after the two-week period. When comparing the two groups, only the change in ESS was significant (mean difference, control: -0.14 vs. LT: -1.43,
= 0.021) after adjusting for the baseline characteristics. There were no significant differences in serum cortisol or clock genes' expression.
LT can improve daytime sleepiness in patients with sleep disorders; however, further well-designed studies are warranted to confirm its efficacy.</description><subject>Adults</subject><subject>Blood pressure</subject><subject>Care and treatment</subject><subject>Cholesterol</subject><subject>Circadian rhythm</subject><subject>Clinical trials</subject><subject>clock genes</subject><subject>daytime sleepiness</subject><subject>Diabetes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>High density lipoprotein</subject><subject>Homeostasis</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Immunoassay</subject><subject>Insomnia</subject><subject>Insulin</subject><subject>Light</subject><subject>Light therapy</subject><subject>Lipoproteins</subject><subject>Mental disorders</subject><subject>Metabolic disorders</subject><subject>Phototherapy</subject><subject>Sleep apnea</subject><subject>sleep disorder</subject><subject>Sleep disorders</subject><issn>1648-9144</issn><issn>1010-660X</issn><issn>1648-9144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptks1vFCEYxidGY2v17smQePGwU2FgBvBiJk2rm6yp0fVMgIFdNjOwwozN9q-XdWvtNoYD5OV5fm_ej6J4jeA5xhy-H0zntPOy5rBBsGmeFKeoIazkiJCnD94nxYuUNhDiqqbV8-IEU0xJReFpcXtlZHLK9W7cAek7cGmt01LvQLDgS4je-RVYuNV6BMu1iXK7AzZE0HZTPyZw48Y1mPsUBu_kB9CCr64P4wx8y6QwuFvTzcD11vhyIZXpZ2B5E8o2DuD7OHW7l8UzK_tkXt3dZ8WPq8vlxedycf1pftEuSl0jNJbUEqOxxDVvKlibTlvJDLW0UZJbrLWiiCgNNYKWVbRSqKGEMEazCnKDND4r5gduF-RGbKMbZNyJIJ34EwhxJWQcne6NkBhpw4xCqoOEGCWZZhWssKobTDgjmfXxwNpOKjdfGz9G2R9Bj3-8W4tV-CUQxLCGNcqEd3eEGH5OJo1icEmbvpfehCmJiuE8yBqRJkvfPpJuwhR97lVWVZzhPF7-T7WSuQLnbciJ9R4qWlozzGvK92nP_6PKpzOD08Eb63L8yAAPBh1DStHY-yIRFPvlE4-XL1vePGzOveHvtuHf09bVVA</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Yoon, Jihyun</creator><creator>Heo, Seokjae</creator><creator>Lee, Hyangkyu</creator><creator>Sul, Eungyeong</creator><creator>Han, Taehwa</creator><creator>Kwon, Yu-Jin</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9021-3856</orcidid><orcidid>https://orcid.org/0000-0002-7328-7765</orcidid><orcidid>https://orcid.org/0000-0002-0821-6020</orcidid><orcidid>https://orcid.org/0000-0002-8764-7995</orcidid><orcidid>https://orcid.org/0000-0002-1057-2235</orcidid></search><sort><creationdate>20230601</creationdate><title>Feasibility and Efficacy of Morning Light Therapy for Adults with Insomnia: A Pilot, Randomized, Open-Label, Two-Arm Study</title><author>Yoon, Jihyun ; Heo, Seokjae ; Lee, Hyangkyu ; Sul, Eungyeong ; Han, Taehwa ; Kwon, Yu-Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-7f4ec3a3596205edcfa8e7f76ba9f3ccb714bc0c10f8272b16744887a8e09e1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adults</topic><topic>Blood pressure</topic><topic>Care and treatment</topic><topic>Cholesterol</topic><topic>Circadian rhythm</topic><topic>Clinical trials</topic><topic>clock genes</topic><topic>daytime sleepiness</topic><topic>Diabetes</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>High density lipoprotein</topic><topic>Homeostasis</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Immunoassay</topic><topic>Insomnia</topic><topic>Insulin</topic><topic>Light</topic><topic>Light therapy</topic><topic>Lipoproteins</topic><topic>Mental disorders</topic><topic>Metabolic disorders</topic><topic>Phototherapy</topic><topic>Sleep apnea</topic><topic>sleep disorder</topic><topic>Sleep disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, Jihyun</creatorcontrib><creatorcontrib>Heo, Seokjae</creatorcontrib><creatorcontrib>Lee, Hyangkyu</creatorcontrib><creatorcontrib>Sul, Eungyeong</creatorcontrib><creatorcontrib>Han, Taehwa</creatorcontrib><creatorcontrib>Kwon, Yu-Jin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Medicina (Kaunas, Lithuania)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, Jihyun</au><au>Heo, Seokjae</au><au>Lee, Hyangkyu</au><au>Sul, Eungyeong</au><au>Han, Taehwa</au><au>Kwon, Yu-Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility and Efficacy of Morning Light Therapy for Adults with Insomnia: A Pilot, Randomized, Open-Label, Two-Arm Study</atitle><jtitle>Medicina (Kaunas, Lithuania)</jtitle><addtitle>Medicina (Kaunas)</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>59</volume><issue>6</issue><spage>1066</spage><pages>1066-</pages><issn>1648-9144</issn><issn>1010-660X</issn><eissn>1648-9144</eissn><abstract>Light therapy (LT) is used as an adjunctive treatment for sleep problems. This study evaluates the impact of LT on sleep quality and sleep-related parameters in patients with sleep disorders.
We performed a pilot, randomized, open-label clinical trial. Fourteen patients aged 20-60 years with insomnia were randomized into the control and LT groups (1:1 ratio). The LT group was instructed to use a device that provides bright LT (6000 K, 380 lux, wavelength 480 nm) for at least 25 min before 09:00 a.m. for two weeks. A self-reported questionnaire was used to evaluate circadian preference, mood, and sleep-related parameters. We analyzed serum cortisol levels and clock genes' expression.
The Epworth Sleepiness Scale (ESS), insomnia severity index(ISI), and Pittsburgh Sleep Quality index(PSQI) were significantly improved within the LT group only after the two-week period. When comparing the two groups, only the change in ESS was significant (mean difference, control: -0.14 vs. LT: -1.43,
= 0.021) after adjusting for the baseline characteristics. There were no significant differences in serum cortisol or clock genes' expression.
LT can improve daytime sleepiness in patients with sleep disorders; however, further well-designed studies are warranted to confirm its efficacy.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37374270</pmid><doi>10.3390/medicina59061066</doi><orcidid>https://orcid.org/0000-0002-9021-3856</orcidid><orcidid>https://orcid.org/0000-0002-7328-7765</orcidid><orcidid>https://orcid.org/0000-0002-0821-6020</orcidid><orcidid>https://orcid.org/0000-0002-8764-7995</orcidid><orcidid>https://orcid.org/0000-0002-1057-2235</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Adults Blood pressure Care and treatment Cholesterol Circadian rhythm Clinical trials clock genes daytime sleepiness Diabetes Ethylenediaminetetraacetic acid High density lipoprotein Homeostasis Hospitals Hypertension Immunoassay Insomnia Insulin Light Light therapy Lipoproteins Mental disorders Metabolic disorders Phototherapy Sleep apnea sleep disorder Sleep disorders |
| title | Feasibility and Efficacy of Morning Light Therapy for Adults with Insomnia: A Pilot, Randomized, Open-Label, Two-Arm Study |
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