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Non-invasive exploration of metabolic profile of lung cancer with Magnetic Resonance Spectroscopy and Mass Spectrometry

AbstractBackgroundLung cancer is a major cause of global morbidity and mortality. Current low dose CT screening is invasive and its role remains contentious. There are no known biomarkers to monitor treatment response, detect disease recurrence and patient selection for adjuvant treatment after cura...

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Published in:Contemporary clinical trials communications 2019-12, Vol.16, p.100445-100445, Article 100445
Main Authors: Ahmed, Naseer, Kidane, Biniam, Wang, Le, Tan, Lawrence, Buduhan, Gordon, Srinathan, Sadeesh, Aliani, Michel
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container_start_page 100445
container_title Contemporary clinical trials communications
container_volume 16
creator Ahmed, Naseer
Kidane, Biniam
Wang, Le
Tan, Lawrence
Buduhan, Gordon
Srinathan, Sadeesh
Aliani, Michel
description AbstractBackgroundLung cancer is a major cause of global morbidity and mortality. Current low dose CT screening is invasive and its role remains contentious. There are no known biomarkers to monitor treatment response, detect disease recurrence and patient selection for adjuvant treatment after curative surgical resection. Hence there is an urgent need to explore non-conventional and noninvasive tools to develop novel biomarkers to improve the outcome of this lethal cancer. MethodsThis is an ongoing exploratory and translational study involving collection of bio fluids from 50 patients with early stage non-small cell lung cancer before and after surgical resection. The primary Objective is to identify cancer specific metabolome in body fluids - sputum, exhaled breath condensate, blood and urine of the patients with early stage non-small. cell lung cancer (NSCLC) using Magnetic Resonance Spectroscopy (MRS) and Mass Spectroscopy (MS). ConclusionThe trajectory of change in metabolic profile of body fluids before and after surgical resection may have potential clinical applications in lung cancer screening, as biomarkers for disease recurrence and exploration of novel targets for therapeutic intervention.
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Current low dose CT screening is invasive and its role remains contentious. There are no known biomarkers to monitor treatment response, detect disease recurrence and patient selection for adjuvant treatment after curative surgical resection. Hence there is an urgent need to explore non-conventional and noninvasive tools to develop novel biomarkers to improve the outcome of this lethal cancer. MethodsThis is an ongoing exploratory and translational study involving collection of bio fluids from 50 patients with early stage non-small cell lung cancer before and after surgical resection. The primary Objective is to identify cancer specific metabolome in body fluids - sputum, exhaled breath condensate, blood and urine of the patients with early stage non-small. cell lung cancer (NSCLC) using Magnetic Resonance Spectroscopy (MRS) and Mass Spectroscopy (MS). ConclusionThe trajectory of change in metabolic profile of body fluids before and after surgical resection may have potential clinical applications in lung cancer screening, as biomarkers for disease recurrence and exploration of novel targets for therapeutic intervention.</description><identifier>ISSN: 2451-8654</identifier><identifier>EISSN: 2451-8654</identifier><identifier>DOI: 10.1016/j.conctc.2019.100445</identifier><identifier>PMID: 31650068</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Biomarkers ; Lung cancer ; Metabolomics ; Other</subject><ispartof>Contemporary clinical trials communications, 2019-12, Vol.16, p.100445-100445, Article 100445</ispartof><rights>2019 The Author(s)</rights><rights>2019 The Author(s).</rights><rights>2019 The Author(s) 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-9037713d1460cfc82b378d5598d25b9ce4fe065762d7bef1180aedf937e7a5143</citedby><cites>FETCH-LOGICAL-c584t-9037713d1460cfc82b378d5598d25b9ce4fe065762d7bef1180aedf937e7a5143</cites><orcidid>0000-0002-4972-3619 ; 0000-0002-7869-2487</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804748/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2451865419302078$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3549,27924,27925,45780,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31650068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Naseer</creatorcontrib><creatorcontrib>Kidane, Biniam</creatorcontrib><creatorcontrib>Wang, Le</creatorcontrib><creatorcontrib>Tan, Lawrence</creatorcontrib><creatorcontrib>Buduhan, Gordon</creatorcontrib><creatorcontrib>Srinathan, Sadeesh</creatorcontrib><creatorcontrib>Aliani, Michel</creatorcontrib><title>Non-invasive exploration of metabolic profile of lung cancer with Magnetic Resonance Spectroscopy and Mass Spectrometry</title><title>Contemporary clinical trials communications</title><addtitle>Contemp Clin Trials Commun</addtitle><description>AbstractBackgroundLung cancer is a major cause of global morbidity and mortality. Current low dose CT screening is invasive and its role remains contentious. There are no known biomarkers to monitor treatment response, detect disease recurrence and patient selection for adjuvant treatment after curative surgical resection. Hence there is an urgent need to explore non-conventional and noninvasive tools to develop novel biomarkers to improve the outcome of this lethal cancer. MethodsThis is an ongoing exploratory and translational study involving collection of bio fluids from 50 patients with early stage non-small cell lung cancer before and after surgical resection. The primary Objective is to identify cancer specific metabolome in body fluids - sputum, exhaled breath condensate, blood and urine of the patients with early stage non-small. cell lung cancer (NSCLC) using Magnetic Resonance Spectroscopy (MRS) and Mass Spectroscopy (MS). 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subjects Biomarkers
Lung cancer
Metabolomics
Other
title Non-invasive exploration of metabolic profile of lung cancer with Magnetic Resonance Spectroscopy and Mass Spectrometry
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