The Bucherer-Bergs Multicomponent Synthesis of Hydantoins-Excellence in Simplicity

Hydantoins and their hybrids with other molecules represent a very important group of heterocycles because they exhibit diverse biological and pharmacological activities in medicinal and agrochemical applications. They also serve as key precursors in the chemical or enzymatic synthesis of significan...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-06, Vol.26 (13), p.4024
Main Authors: Kalník, Martin, Gabko, Peter, Bella, Maroš, Koóš, Miroslav
Format: Article
Language:English
Subjects:
Acetals
Agrochemicals
Agrochemicals - chemical synthesis
Agrochemicals - chemistry
aldehyde
Bucherer–Bergs reaction
Carbon
Carbonyl compounds
Carbonyls
Chemistry Techniques, Synthetic
Convulsions & seizures
Enzymatic synthesis
Ethanol
Hybrids
Hydantoin
hydantoins
Hydantoins - chemical synthesis
Hydantoins - chemistry
Hyperthermia
ketone
Molecular Structure
multicomponent reaction
Natural products
Organic compounds
Potassium
Review
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Summary:Hydantoins and their hybrids with other molecules represent a very important group of heterocycles because they exhibit diverse biological and pharmacological activities in medicinal and agrochemical applications. They also serve as key precursors in the chemical or enzymatic synthesis of significant nonnatural α-amino acids and their conjugates with medical potential. This review provides a comprehensive treatment of the synthesis of hydantoins via the Bucherer-Bergs reaction including the Hoyer modification but limited to free carbonyl compounds or carbonyl compounds protected as acetals (ketals) and cyanohydrins used as starting reaction components. In this respect, the Bucherer-Bergs reaction provides an efficient and simple method in the synthesis of important natural products as well as for the preparation of new organic compounds applicable as potential therapeutics. The scope and limitations, as well as a comparison with some other methods for preparing hydantoins, are also discussed.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26134024