Changes in voiding behavior in a mouse model of Alzheimer's disease

Besides cognitive decline and behavioral alteration, urinary incontinence often occurs in patients suffering from Alzheimer's disease (AD). To determine whether the transgenic mouse model of AD, APP/PS1 (APP(SL)/PS1(M146L)) mouse, shows alteration of the urinary bladder function and anxiety, as...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2015-08, Vol.7, p.160-160
Main Authors: Biallosterski, B T, Prickaerts, J, Rahnama'i, M S, de Wachter, S, van Koeveringe, G A, Meriaux, C
Format: Article
Language:English
Subjects:
Alzheimer’s disease
Animal cognition
Anxiety
Behavior
Bladder
Cognitive ability
Dementia
Emotional behavior
Experiments
Filter paper
Locomotion
Locomotor activity
locomotor behavior
Males
Marking behavior
Mental health
Metabolism
mouse model
Neuroscience
Neurosciences
Physiology
Presenilin 1
Transgenic mice
Urinary bladder
Urinary incontinence
Urine
Urogenital system
Urology
voiding behavior
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Summary:Besides cognitive decline and behavioral alteration, urinary incontinence often occurs in patients suffering from Alzheimer's disease (AD). To determine whether the transgenic mouse model of AD, APP/PS1 (APP(SL)/PS1(M146L)) mouse, shows alteration of the urinary bladder function and anxiety, as for patients with AD, we examined the urinary marking behavior in relation to affective behavior. At 18 months of age voiding behavior of APP/PS1 and wild type (WT) mice was assessed by using a modified filter paper assay in combination with video tracing, with the cage divided into a center and corner zones. Anxiety-related behavior and locomotion were respectively tested in an elevated zero maze (EZM) and an open field (OF). The APP/PS1 mice urinated more in the center zone than the WT mice. The total volume of markings was significantly lower in the APP/PS1 mice. In both groups, the average volume of a marking in the corner zone was larger than in the center zone. In the EZM, the APP/PS1 mice spent less time in the open arms of the arena, considered as anxiogenic zones, than the WT mice. During the OF task, the APP/PS1 mice covered a longer distance than the WT mice. These findings show that the APP/PS1 mice have a different voiding behavior compared to the WT mice, i.e., urinating with small volumes and voiding in the center of the cage, and suggest that increased locomotor activity and anxiety-related behaviors are factors in the change in voiding pattern in the APP/PS1 mouse.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2015.00160