Renoprotective effect of Nigella sativa against cisplatin-induced nephrotoxicity and oxidative stress in rat

Cisplatin is one of the important antineoplastic drugs. Its clinical use has been restricted due to severe kidney toxicity. Nigella sativa (N. sativa) is an herbaceous plant with many pharmacologic effects. In the present study, we evaluated the protective effects of aqueousethanolic extract of N. s...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2018, Vol.29 (1), p.19-29
Main Authors: Muhibbati, Rida, Husayniyan, Sarah, Shahraki, Samirah, Khuzai, Majid, Rushan, Numa Muhammadian, Hadjzadeh, Musa al-Rida, Rad, Abu al-Fadl Khajavi
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Chemotherapy
Kidney diseases
Kidneys
Nigella sativa
Oxidative stress
Patient outcomes
Properties
Rodents
Seeds
Treatment outcome
Vitamin E
الآثار الفسيولوجية
الإجهاد التأكسدي
الجرذان
الحبة السوداء
السمية الكلوية
سيسبلاتين
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Summary:Cisplatin is one of the important antineoplastic drugs. Its clinical use has been restricted due to severe kidney toxicity. Nigella sativa (N. sativa) is an herbaceous plant with many pharmacologic effects. In the present study, we evaluated the protective effects of aqueousethanolic extract of N. sativa and Vitamin E on cisplatin-induced nephrotoxicity in rats. Eighty male rats were divided into eight groups: control, cisplatin (6 mg/kg; ip), preventive Vitamin E (100 mg/kg), preventive N. sativa (100,200 mg/kg), preventive + treatment Vitamin E, and preventive + treatment N. sativa (100, 200 mg/kg). Duration of this study was 11 days and cisplatin was injected on the 6th day of the experiment. Tissue damage in all groups that received N. sativa extract and Vitamin E showed a significant improvement compared with the cisplatin group. In addition, serum and tissue total thiol content in preventive and preventive + treatment N. sativa groups showed significant increase compared with cisplatin group. There was no significant difference in serum malondialdehyde concentration of the control rats compared with the preventive and preventive + treatment N. sativa groups. N. sativa extract and viamin E improved the pathology and oxidative stress in the rat kidney. However, more studies are needed to determine the mechanism of action of N. sativa on cisplatin-induced kidney toxicity
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.225208