Morphofunctional efficacy of Phyllanthus amarus alkaloid extract on semen quality, hormonal profile and gonadal histomorphometric status in Plasmodium berghei-induced mice

•Phyllanthus amarus alkaloid extract (PAAE).•PAAE possesses antimalarial activity.•PAAE has capacity to alleviate plasmodium infection.•PAAE possess potent anti-malarial activity with reputable parasite clearance.•Plasmodium berghei has deleterious effect on histomorphometric features of mice. The m...

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Bibliographic Details
Published in:Food chemistry advances 2024-12, Vol.5, p.100821, Article 100821
Main Authors: Ojugbeli, Evelyn Tarela, Okom, Solomon Ugochukwu, Nwogueze, Bartholomew Chukwuebuka, Toloyai, Pere-Ebi Yabrade, Onyesom, Innocent
Format: Article
Language:English
Subjects:
Alkaloid
Hormone
Malaria
Phyllanthus amarus
Plasmodium berghei
Semen
Testes
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Summary:•Phyllanthus amarus alkaloid extract (PAAE).•PAAE possesses antimalarial activity.•PAAE has capacity to alleviate plasmodium infection.•PAAE possess potent anti-malarial activity with reputable parasite clearance.•Plasmodium berghei has deleterious effect on histomorphometric features of mice. The mainstay for malaria treatment is drug, but currently, the treatment is failing and making malaria infection worrisome. The alkaloid extract of the plant Phyllanthus amarus has been demonstrated to possess antimalarial activity. This present study evaluated the changes in semen quality, hormone profile and gonadal histomorphometric features in Berghei-induced mice treated with alkaloid extract of Phyllanthus amarus. Thirty-six BALB/c mice were divided into six groups (n=6 per group). The first two groups were positive (not infected, not treated) and negative (infected, but not treated) control mice, while the remaining groups (Groups 3–6) were the experimental mice infected with Plasmodium berghei (NK 65) malaria parasite and respectively treated with standard drug Lonart® DS (20 mg/kg) with 75 mg/kg, 150 mg/kg and 225 mg/kg of the Phyllanthus amarus alkaloid extract (PAAE) for 4 days. Then, 10 days later, the animals were euthanized and blood samples were collected for biochemical investigation. Testes tissues were harvested for histological assessment and semen samples were collected for analysis using standard procedures and documented methods. Data from our study revealed that Plasmodium berghei malaria-induced infection significantly (p
ISSN:2772-753X
2772-753X
DOI:10.1016/j.focha.2024.100821