Jack-of-all-trades: itaconate tolerizes NLRP3 inflammasome activation

Immune responses must be tightly regulated in order to avoid excessive inflammation. In this issue of Cell Reports, Bambouskova et al. (2021) demonstrate that itaconate and iNOS collaborate to tolerize the NLRP3 inflammasome, thereby limiting cytokine secretion and cell death. Immune responses must...

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Bibliographic Details
Published in:Cell reports (Cambridge) 2021-03, Vol.34 (10), p.108855-108855, Article 108855
Main Authors: Fischer, Natasha Lopes, Shin, Sunny, Brodsky, Igor E.
Format: Article
Language:English
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Summary:Immune responses must be tightly regulated in order to avoid excessive inflammation. In this issue of Cell Reports, Bambouskova et al. (2021) demonstrate that itaconate and iNOS collaborate to tolerize the NLRP3 inflammasome, thereby limiting cytokine secretion and cell death. Immune responses must be tightly regulated in order to avoid excessive inflammation. In this issue of Cell Reports, Bambouskova et al. (2021) demonstrate that itaconate and iNOS collaborate to tolerize the NLRP3 inflammasome, thereby limiting cytokine secretion and cell death.
ISSN:2211-1247
2211-1247
DOI:10.1016/j.celrep.2021.108855