Trophoblast Cell Function in the Antiphospholipid Syndrome

Antiphospholipid syndrome (APS) is a complex thrombo-inflammatory autoimmune disease characterized by the presence of antiphospholipid antibodies (aPL). Women with APS are at high risk of recurrent early pregnancy loss as well as late obstetrical complications—premature birth due to placental insuff...

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Bibliographic Details
Published in:Biomedicines 2023-09, Vol.11 (10), p.2681
Main Authors: Vrzić Petronijević, Svetlana, Vilotić, Aleksandra, Bojić-Trbojević, Žanka, Kostić, Sanja, Petronijević, Miloš, Vićovac, Ljiljana, Jovanović Krivokuća, Milica
Format: Article
Language:English
Subjects:
Anticoagulants
Antiphospholipid antibodies
Antiphospholipid syndrome
Autoimmune diseases
Blood clot
Cell survival
Infants (Premature)
Internalization
Lupus
ncRNA
Obstetrics
Placenta
Pre-eclampsia
Pregnancy complications
Premature birth
Review
Reviews
Thrombosis
trophoblast
Womens health
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Summary:Antiphospholipid syndrome (APS) is a complex thrombo-inflammatory autoimmune disease characterized by the presence of antiphospholipid antibodies (aPL). Women with APS are at high risk of recurrent early pregnancy loss as well as late obstetrical complications—premature birth due to placental insufficiency or severe preeclampsia. Accumulating evidence implies that vascular thrombosis is not the only pathogenic mechanism in obstetric APS, and that the direct negative effect of aPL on the placental cells, trophoblast, plays a major role. In this review, we summarize the current findings regarding the potential mechanisms involved in aPL-induced trophoblast dysfunction. Introduction on the APS and aPL is followed by an overview of the effects of aPL on trophoblast—survival, cell function and aPL internalization. Finally, the implication of several non-coding RNAs in pathogenesis of obstetric APS is discussed, with special emphasis of their possible role in trophoblast dysfunction and the associated mechanisms.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11102681