Screening of Trace Elements in Hair of the Female Population with Different Types of Cancers in Wielkopolska Region of Poland

Background. Cancer constitutes a major health problem worldwide. Thus, search for reliable and practical markers of the disease process remains the key issue of the diagnostic process. Objectives. The study aims at linking the trace element status of an organism, assessed by hair analysis, with the...

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Bibliographic Details
Published in:TheScientificWorld 2014, Vol.2014 (2014), p.1-15
Main Authors: Seremak-Mrozikiewicz, Agnieszka, Ożarowski, Marcin, Krupka, Krzysztof, Czerny, Bogusław
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Biopsy
Boron
Breast cancer
Cancer
Case-Control Studies
Chemical elements
Diagnosis
Female
Females
Germanium
Glycolysis
Hair
Hair - chemistry
Hair analysis
Health aspects
Heavy metals
Hormones - metabolism
Hospitals
Humans
Lymphoma
Magnesium
Mass spectrometry
Metal concentrations
Methods
Middle Aged
Neoplasms - metabolism
Physiology
Poland
Selenium
Studies
Trace analysis
Trace elements
Trace Elements - analysis
Womens health
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Summary:Background. Cancer constitutes a major health problem worldwide. Thus, search for reliable and practical markers of the disease process remains the key issue of the diagnostic process. Objectives. The study aims at linking the trace element status of an organism, assessed by hair analysis, with the occurrence of cancer diseases. Material and Methods. Hair samples were collected from 299 patients with cancer diseases confirmed by a histopathological test and from 100 controls. Cancer patients were divided into three groups, depending on cancer type: hormone-dependent cancer, cancer of the alimentary tract, and cancer with high glycolytic activity. Mineral element analysis of hair was performed using an atomic emission spectrophotometer with inductively coupled plasma (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Results. Statistically significantly lower concentrations of selenium, zinc, copper, germanium and boron, iron, and magnesium were observed in the three groups of cancer patients. Disturbance in the axis glucose-insulin and changes in concentrations of heavy metals and toxic elements were also noted. Conclusions. It seems safe to conclude that our results confirmed usefulness of hair element analysis in screening tests for the assessment of the biomarker of various cancer diseases in a female population.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2014/953181