Importance of TP53 codon 72 and intron 3 duplication 16 bp polymorphisms and their haplotypes in susceptibility to sarcopenia in Iranian older adults

Sarcopenia is described as age-related progressive skeletal muscle failure that results in marked reduction in the patient's independence and life quality. In this study, we explored the association of TP53 exon 4 Arg72pro (rs1042522) and Intron 3 16-bp Del/Ins (rs17878362) polymorphisms and th...

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Bibliographic Details
Published in:BMC geriatrics 2022-02, Vol.22 (1), p.103-103, Article 103
Main Authors: Montazeri-Najafabady, Nima, Dabbaghmanesh, Mohammad Hossein, Nasimi, Nasrin, Sohrabi, Zahra, Estedlal, Alireza, Asmarian, Naeimehossadat
Format: Article
Language:English
Subjects:
Age
Aged
Aging
Apoptosis
Body composition
Body mass index
Cell cycle
Cholesterol
Codon
Demographic aspects
Fasting
Gene polymorphism
Genes
Genetic aspects
Geriatrics
Hand Strength
Haplotypes
Haplotypes - genetics
Health aspects
High density lipoprotein
Homeostasis
Humans
Introns - genetics
Iran - epidemiology
Lipid profile
Low density lipoprotein
Muscle function
Muscle strength
Muscles
Musculoskeletal system
Older people
p53
Polymorphism
Polymorphism, Genetic
Proline
Proteins
Quality of life
Risk factors
Sarcopenia
Sarcopenia - diagnosis
Sarcopenia - epidemiology
Sarcopenia - genetics
Skeletal muscle
Triglycerides
Tumor Suppressor Protein p53 - genetics
Working groups
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Summary:Sarcopenia is described as age-related progressive skeletal muscle failure that results in marked reduction in the patient's independence and life quality. In this study, we explored the association of TP53 exon 4 Arg72pro (rs1042522) and Intron 3 16-bp Del/Ins (rs17878362) polymorphisms and their haplotypes with sarcopenia, anthropometric, body composition and biochemical parameters. A total of 254 older individuals (65 sarcopenic and 189 healthy) were recruited in this research and genotyped by PCR-RFLP. Linear regression was applied to find the correlation between TP53 polymorphism, and biochemical and anthropometric parameters. The correlation between TP53 polymorphism and haplotypes and the risk of sarcopenia was investigated by logistic regression. Arg/Pro genotype carriers was at a lower (OR  = 0.175, 95% CI = 0.068 - 0.447; P 
ISSN:1471-2318
1471-2318
DOI:10.1186/s12877-022-02765-6