Short-term effect of prebiotics administration on stool characteristics and serum cytokines dynamics in very young children with acute diarrhea

We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9-24 months) with acute diarrhea. Interl...

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Bibliographic Details
Published in:Nutrients 2010-07, Vol.2 (7), p.683-692
Main Authors: Vaisman, Nachum, Press, Josef, Leibovitz, Eugene, Boehm, Güenther, Barak, Vivian
Format: Article
Language:English
Subjects:
Acute Disease
Antibiotics
Beer
Breastfeeding & lactation
Child, Preschool
Cytokines
Cytokines - blood
Diarrhea
Diarrhea - drug therapy
Diarrhea - microbiology
Diarrhea - physiopathology
Dietary Supplements
Double-Blind Method
Emergency medical care
Feces - microbiology
fructo-oligosaccharides
galacto-oligosaccharides
Galactose - administration & dosage
galacturonic oligosaccharides
Humans
Immune system
Infant
infants
Interleukins - blood
Medical research
Microbiota
Oligosaccharides - administration & dosage
Pathogens
Pediatrics
Placebos
Prebiotics
Probiotics
Prospective Studies
Tumor Necrosis Factor-alpha - blood
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Summary:We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9-24 months) with acute diarrhea. Interleukin-1 (IL-1), IL-1RA, IL-6, IL-8, IL-10, TNF-α and sIL-2R cytokine levels were determined. The significant decrease in number of stools and increase in stool consistency in the supplemented group was of little clinical relevance. The only significant change in pro- and anti-inflammatory cytokines was decreased TNF-α levels in the supplemented group. Prebiotic supplementation during acute diarrhea episodes did not influence the clinical course.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu2070683