One‐year survival after out‐of‐ hospital cardiac arrest: Sex‐based survival analysis in a Canadian population

Objective We investigated sex differences in 1‐year survival in a cohort of patients who survived out‐of‐hospital cardiac arrest (OHCA) to hospital discharge. We hypothesized that female sex is associated with higher 1‐year posthospital discharge survival. Methods A retrospective analysis of linked...

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Published in:Journal of the American College of Emergency Physicians Open 2023-06, Vol.4 (3), p.e12957-n/a
Main Authors: Awad, Emad, Fordyce, Christopher B., Grunau, Brian, Christenson, Jim, Helmer, Jennie, Humphries, Karin
Format: Article
Language:English
Subjects:
Cardiac arrest
Cardiopulmonary resuscitation
Cardiovascular disease
Coronary vessels
CPR
Diabetes
Emergency Medical Services
Females
Gender differences
Heart attacks
Heart failure
Hospitals
Hypertension
Kidney diseases
Males
Missing data
Mortality
Original Research
sex
survival
Survival analysis
Variables
Vein & artery diseases
Vital statistics
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Summary:Objective We investigated sex differences in 1‐year survival in a cohort of patients who survived out‐of‐hospital cardiac arrest (OHCA) to hospital discharge. We hypothesized that female sex is associated with higher 1‐year posthospital discharge survival. Methods A retrospective analysis of linked data (2011–2017) from clinical databases in British Columbia (BC) was conducted. We used Kaplan–Meier curves, stratified by sex, to display survival up to 1‐year, and the log‐rank test to test for significant sex differences. This was followed by multivariable Cox proportional hazards analysis to investigate the association between sex and 1‐year mortality. The multivariable analysis adjusted for variables known to be associated with survival, including variables related to OHCA characteristics, comorbidities, medical diagnoses, and in‐hospital interventions. Results We included 1278 hospital‐discharge survivors; 284 (22.2%) were female. Females had a lower proportion of OHCA occurring in public locations (25.7% vs. 44.0%, P 
ISSN:2688-1152
2688-1152
DOI:10.1002/emp2.12957