Review of survival, safety, and clinical outcomes in HER2+ metastatic gastric cancer following the administration of trastuzumabPost-Trastuzumab Gastric Cancer

• Published in: Cancer treatment and research communications 2020, Vol.24, p.100189, Article 100189
• Main Authors: Hackshaw, Michelle D., Bui, Christine L., Ladner, Amy, Tu, Nora, Islam, Zahidul, Ritchey, Mary E., Salas, Maribel
• Format: Article
• Language: English
• Subjects: Anti-HER2 therapy; HER2; Metastatic gastric cancer; Review; Trastuzumab
• ISSN: 2468-2942; 2468-2942
• DOI: 10.1016/j.ctarc.2020.100189

•Trastuzumab-treated patients have longer survival times.•Trastuzumab-based chemotherapy appeared to improve survival and clinical outcomes regardless of tumor location.•Gap in the knowledge of the effect of HER2 heterogeneity on clinical outcomes. Therapies targeting human epidermal growth factor receptor 2 (HER2) have become a focus for improving treatment outcomes in patients with gastric cancer. This literature review sought to assesses clinical outcomes, including safety, survival, and treatment outcomes, of patients who received trastuzumab for the treatment of HER2+ metastatic gastric cancer. Searches were conducted in PubMed and Embase to identify observational research studies investigating the clinical outcomes of trastuzumab and combination therapies for the treatment of HER2+ metastatic gastric cancer, published January 1, 2014–August 22, 2019. Article screening was a two-phase process, and the results of each screening level were documented in accordance with PRISMA. Twenty articles met the selection criteria for data extraction. Studies focused on treatment patterns or survival, safety, and clinical outcomes, as well as the natural history of disease. In the combined HER2+ patient populations included in this review, tumors were located in the stomach (33.7%), gastroesophageal junction (GEJ, 14.2%), unspecific GEJ or stomach (50.3%), or esophagus (1.9%). Studies observed increases in both overall survival and progression-free survival with the use of trastuzumab-based chemotherapy compared with chemotherapy treatment alone. Additionally, trastuzumab-based chemotherapy appeared to improve survival and clinical outcomes regardless of the presence of multi-organ metastases or tumor location. Trastuzumab-treated patients have longer survival times than those not treated with trastuzumab and tolerate treatment well, with few serious adverse events. New treatments for second- and subsequent-line therapies would increase regimen options. The treatment patterns and clinical outcomes observed in this literature review suggest patients treated with trastuzumab have longer survival times compared with chemotherapy treatment alone and tolerate treatment