Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation

We investigated differences in brain activation associated with cognitive fatigue between persons with traumatic brain injury (TBI) and healthy controls (HCs). Twenty-two participants with moderate-severe TBI and 20 HCs performed four blocks of a difficult working memory task and four blocks of a co...

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Bibliographic Details
Published in:Scientific reports 2017-08, Vol.7 (1), p.8973-12, Article 8973
Main Authors: Wylie, G. R., Dobryakova, E., DeLuca, J., Chiaravalloti, N., Essad, K., Genova, H.
Format: Article
Language:English
Subjects:
59/36
631/378/1457/1936
631/477/2811
Adult
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - pathology
Brain mapping
Caudate nucleus
Caudate Nucleus - pathology
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Cognitive ability
Fatigue
Fatigue - etiology
Fatigue - physiopathology
Female
Functional magnetic resonance imaging
Humanities and Social Sciences
Humans
Magnetic Resonance Imaging
Male
Mental task performance
Middle Aged
multidisciplinary
Neuroimaging
Science
Science (multidisciplinary)
Short term memory
Traumatic brain injury
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Summary:We investigated differences in brain activation associated with cognitive fatigue between persons with traumatic brain injury (TBI) and healthy controls (HCs). Twenty-two participants with moderate-severe TBI and 20 HCs performed four blocks of a difficult working memory task and four blocks of a control task during fMRI imaging. Cognitive fatigue, assessed before and after each block, was used as a covariate to assess fatigue-related brain activation. The TBI group reported more fatigue than the HCs, though their performance was comparable. Regarding brain activation, the TBI group showed a Task X Fatigue interaction in the caudate tail resulting from a positive correlation between fatigue and brain activation for the difficult task and a negative relationship for the control task. The HC group showed the same Task X Fatigue interaction in the caudate head. Because we had prior hypotheses about the caudate, we performed a confirmatory analysis of a separate dataset in which the same subjects performed a processing speed task. A relationship between Fatigue and brain activation was evident in the caudate for this task as well. These results underscore the importance of the caudate nucleus in relation to cognitive fatigue.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-08846-6