Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study

• Published in: BMC infectious diseases 2019-03, Vol.19 (1), p.253-253, Article 253
• Main Authors: Kolozsvári, László Róbert, Kónya, József, Paget, John, Schellevis, Francois G, Sándor, János, Szőllősi, Gergő József, Harsányi, Szilvia, Jancsó, Zoltán, Rurik, Imre
• Format: Article
• Language: English
• Subjects: Adults; Age; Antibacterial agents; Antibacterial resistance; Antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Antimicrobial resistance; Care and treatment; Children; Clarithromycin; Clindamycin; Commensal; Correlation analysis; Demographics; Drug resistance; Ecological monitoring; Family medicine; Family physicians; Health care; Healthy population; Infectious diseases; Lincosamides; Medical personnel; Microbial drug resistance; Patient-related factors; Patients; Penicillin; Physicians; Pneumococcal infections; Pneumonia; Population; Practice; Primary care; Public health; R&D; Regression analysis; Research & development; Resistance factors; Risk factors; Sociodemographics; Staphylococcus aureus; Staphylococcus aureus infections; Staphylococcus infections; Streptococcus infections; Streptococcus pneumoniae; Studies
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-019-3889-3

Antimicrobial resistance (AMR) is an increasing public health problem worldwide. We studied some patient-related factors that might influence the antimicrobial resistance. and whether the volume of antibiotic prescribing of the primary care physicians correlate with the antibiotic resistance rates of commensal nasal Staphylococcus aureus and Streptococcus pneumoniae. The socio-demographic questionnaires, the antibiotic prescription and resistance data of commensal nasal S. aureus and S. pneumoniae were collected in the 20 participating Hungarian practices of the APRES study. Multivariate logistic regression analyses were performed on the patient-related data and the antimicrobial resistance of the S. aureus and S. pneumoniae on individual, patient level. Ecological analyses were performed with Spearman's rank correlations at practice level, the analyses were performed in the whole sample (all practices) and in the cohorts of primary care practices taking care of adults (adult practices) or children (paediatric practices). According to the multivariate model, age of the patients significantly influenced the antimicrobial resistance of the S. aureus (OR = 0.42, p = 0.004) and S. pneumoniae (OR = 0.89, p