Phytochemical profiling, antioxidant potential and protective effect of leaves extract of tunisian Vitis vinifera autochthonous accessions against acute CCl4-injured hepatotoxicity in mice

Vitis vinifera leaves (VVL) are agro-industrial waste. In the current study, the phytochemical profile of V. vinifera leaves extracts (VVLE) of two Tunisian autochthonous accessions was determined via LC-UV-ESI/MS, and their antioxidant and hepatoprotective properties were also assessed. Mice were p...

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Published in:Heliyon 2023-05, Vol.9 (5), p.e16377-e16377, Article e16377
Main Authors: Saadaoui, Nabil, Mathlouthi, Ahmed, Zaiter, Ali, El-Bok, Safia, Mokni, Moncef, Harbi, Mounira, Ghanem-Boughanmi, Néziha, Dicko, Amadou, Ben-Attia, Mossadok
Format: Article
Language:English
Subjects:
Acute liver injury
Antioxidant activity
Cultivated
Hepatoprotective activity
Vitis vinifera L
Wild
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Summary:Vitis vinifera leaves (VVL) are agro-industrial waste. In the current study, the phytochemical profile of V. vinifera leaves extracts (VVLE) of two Tunisian autochthonous accessions was determined via LC-UV-ESI/MS, and their antioxidant and hepatoprotective properties were also assessed. Mice were pretreated orally with VVLE (7.5, 15 and 30 mg/kg) for 7 days, and then received acutely and by i.p. a solution CCl4 at 12% in sunflower oil (v/v). Serum levels of hepatic markers, oxidative stress indicators in liver tissue and histological changes were assessed. LC-UV-ESI/MS analysis revealed four phenolic compounds identified in both extracts with quercetin-3-O-glucuronide being the dominant constituent (23.32 ± 1.06 vs. 10.24 ± 0.12 mg/g DM, p 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e16377