Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs

Background Upper gastrointestinal (GI) ulceration and bleeding in critically ill dogs can cause severe anemia and increase morbidity. Acid suppressants using proton pump inhibitors or histamine‐2 receptor blockers administered IV is commonly recommended. Hypothesis/Objectives To evaluate the efficac...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2020-03, Vol.34 (2), p.678-683
Main Authors: Kuhl, Amanda, Odunayo, Adesola, Price, Josh, Hecht, Silke, Marshall, Kristen, Steiner, Joerg, Tolbert, M. Katherine
Format: Article
Language:English
Subjects:
Acids
anemia
Animals
Anti-Ulcer Agents - administration & dosage
Anti-Ulcer Agents - therapeutic use
Beagle
bravo monitoring
canine
Catheters
Cross-Over Studies
Dogs
Equality
Esomeprazole - administration & dosage
Esomeprazole - pharmacology
Famotidine - administration & dosage
Famotidine - pharmacology
Feces
Female
gastrointestinal system
hemorrhage
histamine‐2 receptor antagonist
Hydrogen-Ion Concentration
Injections, Intravenous
Male
morbidity
Pantoprazole - administration & dosage
Pantoprazole - pharmacology
proton pump inhibitor
proton pump inhibitors
SMALL ANIMAL
Software
Statistical analysis
Variance analysis
Vomiting
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Summary:Background Upper gastrointestinal (GI) ulceration and bleeding in critically ill dogs can cause severe anemia and increase morbidity. Acid suppressants using proton pump inhibitors or histamine‐2 receptor blockers administered IV is commonly recommended. Hypothesis/Objectives To evaluate the efficacy of IV administered esomeprazole, pantoprazole, and famotidine constant rate infusion (CRI) on increasing the intragastric pH of dogs. We hypothesized that esomeprazole and famotidine CRI would provide superior acid suppression compared to pantoprazole and reach pH goals for the treatment of GI bleeding. Animals Nine healthy research Beagles. Methods Randomized, 3‐way crossover. Dogs received pantoprazole or esomeprazole at 1 mg/kg IV q12h and famotidine with a loading dose of 1 mg/kg followed by 8 mg/kg IV CRI daily for 3 consecutive days. The intragastric pH was recorded at baseline and for 72 hours of treatment. The mean pH and the mean percentage time (MPT) the intragastric pH was ≥3 or ≥4 were compared among and within treatment groups. Results Significant increases in mean pH (P 
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.15718