Characterization of Integrons and Quinolone Resistance in Clinical Escherichia coli Isolates in Mansoura City, Egypt

Escherichia coli is a common pathogen in both humans and animals. Quinolones are used to treat infections caused by Gram-negative bacteria, but resistance genes emerged. Only scarce studies investigated the association between plasmid-mediated quinolone resistance (PMQR) genes and integrons in clini...

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Bibliographic Details
Published in:International journal of microbiology 2021, Vol.2021, p.1-11
Main Authors: Abdel-Rhman, Shaymaa H., Elbargisy, Rehab M., Rizk, Dina E.
Format: Article
Language:English
Subjects:
Acetyltransferase
Aminoglycosides
Antibiotics
Antimicrobial agents
Bacteria
Cassettes
Clinical isolates
Drug resistance
Drug resistance in microorganisms
E coli
Efflux
Enzymes
Escherichia coli
Gastroenterology
Genes
Gram-negative bacteria
Health aspects
Infections
Investigations
Microbiology
Plasmids
Quinolones
Trimethoprim
Urine
Urology
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Summary:Escherichia coli is a common pathogen in both humans and animals. Quinolones are used to treat infections caused by Gram-negative bacteria, but resistance genes emerged. Only scarce studies investigated the association between plasmid-mediated quinolone resistance (PMQR) genes and integrons in clinical isolates of E. coli. The current study investigated the prevalence of quinolone resistance and integrons among 134 clinical E. coli isolates. Eighty (59.70%) isolates were quinolone-resistant, and 60/134 (44.77%) isolates were integron positive with the predominance of class I integrons (98.33%). There was a significant association between quinolone resistance and the presence of integrons (P
ISSN:1687-918X
1687-9198
DOI:10.1155/2021/6468942