Gut virome: The next frontier in the treatment of necrotizing enterocolitis

[10] To restore the balance of the gut bacteriome and reduce the severity of NEC using the gut virome, Brunse et al[11] used a piglet model and showed that orogastric administration of fecal filtrate (containing pure and virus-like particles but not bacteria) could completely prevent NEC, with an in...

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Bibliographic Details
Published in:Chinese medical journal 2024-03, Vol.137 (5), p.562-564
Main Authors: Zeng, Shuqin, Zeng, Li, Yang, Panyu, Zheng, Qu, Wang, Shaopu
Format: Article
Language:English
Subjects:
Bacteria
Feces
Homeostasis
Immune system
Inflammatory bowel disease
Medical prognosis
Newborn babies
Pathogenesis
Pathogens
Pediatrics
Premature babies
Viruses
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Summary:[10] To restore the balance of the gut bacteriome and reduce the severity of NEC using the gut virome, Brunse et al[11] used a piglet model and showed that orogastric administration of fecal filtrate (containing pure and virus-like particles but not bacteria) could completely prevent NEC, with an increase in the diversity of virome in both mucosal and luminal compartments as well as the relative abundance of Streptococcus genus. [...]transkingdom interactions between the gut virome and bacteriome emphasize the need to disclose the contribution of the virome or viral linkage in the context of the balance between NEC and host immunity. [...]the mechanisms underlying the pathogenesis of NEC in preterm infants are still under investigation. Additionally, the gut virome affects the intestinal barrier integrity and immune response of the host, which may be related to the etiology of NEC in preterm infants. [...]we hypothesize that the gut virome is the next frontier in the investigation of NEC, which will deepen our appreciation of its pathology and facilitate the development of effective clinical therapies.
ISSN:0366-6999
2542-5641
2542-5641
DOI:10.1097/CM9.0000000000002921