Fishing Innate Immune System Properties through the Transcriptomic Single-Cell Data of Teleostei

The innate immune system is the first line of defense in multicellular organisms. is widely considered a promising model for IIS-related research, with the most amount of scRNAseq data available among . We summarized the scRNAseq and spatial transcriptomics experiments related to the IIS for zebrafi...

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Bibliographic Details
Published in:Biology (Basel, Switzerland) Switzerland), 2023-12, Vol.12 (12), p.1516
Main Authors: Bobrovskikh, Aleksandr V, Zubairova, Ulyana S, Doroshkov, Alexey V
Format: Article
Language:English
Subjects:
aquaculture
Bone marrow
Cytotoxicity
Danio rerio
Dendritic cells
Developmental stages
drug development
Ecotypes
gene networks
Genomes
Immune system
immunity
Immunology
Innate immunity
Kidneys
Meta-analysis
Microbiota
model organisms
Neutrophils
Organisms
Pathogens
Teleostei
Transcriptomics
Zebrafish
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Summary:The innate immune system is the first line of defense in multicellular organisms. is widely considered a promising model for IIS-related research, with the most amount of scRNAseq data available among . We summarized the scRNAseq and spatial transcriptomics experiments related to the IIS for zebrafish and other from the GEO NCBI and the Single-Cell Expression Atlas. We found a considerable number of scRNAseq experiments at different stages of zebrafish development in organs such as the kidney, liver, stomach, heart, and brain. These datasets could be further used to conduct large-scale meta-analyses and to compare the IIS of zebrafish with the mammalian one. However, only a small number of scRNAseq datasets are available for other fish (turbot, salmon, cavefish, and dark sleeper). Since fish biology is very diverse, it would be a major mistake to use zebrafish alone in fish immunology studies. In particular, there is a special need for new scRNAseq experiments involving nonmodel , e.g., long-lived species, cancer-resistant fish, and various fish ecotypes.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology12121516